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Tuning Magnetic Property and Autophagic Response for Self-Assembled Ni-Co Alloy Nanocrystals

机译：自组装Ni-Co合金纳米晶体的调谐磁性能和自噬响应

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摘要

Induction of autophagy is a common response of cells upon exposure to nanomaterials and represents both a safety concern and an application niche for engineered nanomaterials. Herein, it is reported that the magnetic property and the autophagy-inducing activity for Ni-Co alloy nanocrystal (NC) assemblies can be differentially "tuned" through altering the material composition. A series of Ni-Co alloy NC assemblies, composed of nanoparticles (NPs) with a size of about 30 nm, can be quickly synthesized under microwave irradiation in aqueous solution. A controllable self-assembling effect is observed due to the strong magnetic moment of NPs and external magnetic field. Interestingly, the saturation magnetization (Ms) shows a 'roller coaster' effect with varying component molar ratio, while the autophagy-inducing activity and toxicity of these alloy NCs presents an elevated tendency with the increase of nickel component. The autophagic response partly contributes to the observed cellular toxicity of the NC assemblies, as inhibition of autophagy partially but significantly reduces toxicity. Therefore, through tuning the composition of the alloy, optimal Ni-Co NCs satisfying the needs of different applications such as diagnostic imaging (maximum magnetization and low autophagic response) or magnetically-directed cancer cell killing (maximum autophagic response and sufficient magnetization) may be designed and developed.
机译：自噬诱导是细胞暴露于纳米材料后的常见反应，既代表安全问题，又代表工程纳米材料的应用领域。在此，据报道，可以通过改变材料组成来不同地“调谐” Ni-Co合金纳米晶体（NC）组件的磁性和自噬诱导活性。一系列的Ni-Co合金NC组件，由大小约为30 nm的纳米颗粒（NP）组成，可以在微波辐射下在水溶液中快速合成。由于NP的强磁矩和外部磁场，可以观察到可控的自组装效应。有趣的是，饱和磁化强度（Ms）在组分摩尔比变化时表现出“过山车”效应，而这些合金NCs的自噬诱导活性和毒性随着镍组分的增加而呈现出升高的趋势。自噬反应部分有助于观察到的NC组件的细胞毒性，因为自噬的抑制部分但显着降低了毒性。因此，通过调整合金的成分，可以满足不同应用（例如诊断成像（最大磁化和低自噬反应）或磁性定向杀死癌细胞（最大自噬反应和充分磁化）的需求的最佳Ni-Co NCs。设计和开发。

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  • 来源
    《Advanced Functional Materials》 |2013年第47期|5930-5940|共11页
  • 作者

    Liang Dong; Yun Liu; Yang Lu; Li Zhang; Na Man; Liang Cao; Kai Ma; Duo An; Jun Lin; Yun-Jun Xu; Wei-Ping Xu; Wen-Bin Wu; Shu-Hong Yu; Long-Ping Wen;

  • 作者单位

    Division of Nanomaterials & Chemistry Department of Chemistry National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230026, P. R. China;

    Hefei National Laboratory for Physical Sciences at the Microscale School of Life Sciences University of Science and Technology of China Hefei 230027, P. R. China;

    Division of Nanomaterials & Chemistry Department of Chemistry National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230026, P. R. China;

    Hefei National Laboratory for Physical Sciences at the Microscale School of Life Sciences University of Science and Technology of China Hefei 230027, P. R. China,Department of Urology the First Affiliated Hospital of Anhui Medical University and Institute of Urology Anhui Medical University Hefei 230022, P. R. China;

    Hefei National Laboratory for Physical Sciences at the Microscale School of Life Sciences University of Science and Technology of China Hefei 230027, P. R. China;

    Division of Nanomaterials & Chemistry Department of Chemistry National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230026, P. R. China;

    Division of Nanomaterials & Chemistry Department of Chemistry National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230026, P. R. China;

    Division of Nanomaterials & Chemistry Department of Chemistry National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230026, P. R. China;

    Hefei National Laboratory for Physical Sciences at the Microscale School of Life Sciences University of Science and Technology of China Hefei 230027, P. R. China;

    Division of Nanomaterials & Chemistry Department of Chemistry National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230026, P. R. China,Hefei National Laboratory for Physical Sciences at the Microscale School of Life Sciences University of Science and Technology of China Hefei 230027, P. R. China,Anhui Provincial Hospital Hefei, 230001, P. R.China;

    Hefei National Laboratory for Physical Sciences at the Microscale School of Life Sciences University of Science and Technology of China Hefei 230027, P. R. China;

    Anhui Provincial Hospital Hefei, 230001, P. R.China;

    Division of Nanomaterials & Chemistry Department of Chemistry National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230026, P. R. China;

    Hefei National Laboratory for Physical Sciences at the Microscale School of Life Sciences University of Science and Technology of China Hefei 230027, P. R. China;

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