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首页> 外文期刊>Advanced Functional Materials >Creating a Living Hyaline Cartilage Graft Free from Non-Cartilaginous Constituents: An Intermediate Role of a Biomaterial Scaffold
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Creating a Living Hyaline Cartilage Graft Free from Non-Cartilaginous Constituents: An Intermediate Role of a Biomaterial Scaffold

机译：创建不含非软骨素成分的活性透明软骨移植物：生物材料支架的中间作用

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摘要

A novel living hyaline cartilage graft (LhCG) with controllable dimensions and free of non-cartilaginous constituents for articular regeneration is developed. As a living graft for regenerative medicine, LhCG is purely living tissue based and truly scaffold-free. The process of neotissue formation in LhCG is mediated by an interim biomaterial-based novel scaffolding system. This design highlights a philosophy of using biomaterials in engineered regenerative medicine as a transient guiding facility rather than a permanent part of substitute. The fabrication is designed and practiced in a continuous and integrated process, which attributes to its simplicity in operation. Because of the intrinsic non-ceil-adhesive property of hydrogel scaffolds, articular chondro-cytes' phenotype is always preserved throughout the whole procedure, which has been tested and approved both in vitro and in vivo. In situ grafting trials in a rabbit model showcase high success rates in both cartilage repair and graft-host integration. Beyond cartilage repair, this LhCC model may provide a living-tissue-based open platform or niche for multi-tissue regenerations.
机译：开发了一种新型的活体透明软骨移植物（LhCG），其尺寸可控并且不含用于关节再生的非软骨成分。作为再生医学的活体移植物，LhCG纯粹是基于活体组织，并且完全没有支架。 LhCG中新组织形成的过程是由基于临时生物材料的新型支架系统介导的。该设计突出了在工程再生医学中使用生物材料作为一种暂时性的指导手段，而不是替代品的永久组成部分的理念。该制造以连续和集成的过程进行设计和实践，这归因于其操作的简便性。由于水凝胶支架固有的非细胞粘附特性，在整个过程中始终保留关节软骨细胞的表型，该表型已在体外和体内进行了测试和批准。在兔模型中进行的原位移植试验显示出在软骨修复和移植物-宿主整合中的高成功率。除了软骨修复外，这种LhCC模型还可以为多组织再生提供基于活组织的开放平台或利基市场。

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  • 来源
    《Advanced Functional Materials》 |2012年第5期|p.972-978|共7页
  • 作者

    Kai Su; Ting Ting Lau; Wenyan Leong; Yihong Cong; Dong-An Wang;

  • 作者单位

    Division of Bioengineering School of Chemical &. Biomedical Engineering Nanyang Technological University 70 Nanyang Drive, N1.3-B2-13, 637457 Singapore;

    Division of Bioengineering School of Chemical &. Biomedical Engineering Nanyang Technological University 70 Nanyang Drive, N1.3-B2-13, 637457 Singapore;

    Division of Bioengineering School of Chemical &. Biomedical Engineering Nanyang Technological University 70 Nanyang Drive, N1.3-B2-13, 637457 Singapore;

    Division of Bioengineering School of Chemical &. Biomedical Engineering Nanyang Technological University 70 Nanyang Drive, N1.3-B2-13, 637457 Singapore;

    Division of Bioengineering School of Chemical &. Biomedical Engineering Nanyang Technological University 70 Nanyang Drive, N1.3-B2-13, 637457 Singapore;

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