• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced Functional Materials >Colorimetric Detection of Warfare Gases by Polydiacetylenes Toward Equipment-Free Detection
【24h】

Colorimetric Detection of Warfare Gases by Polydiacetylenes Toward Equipment-Free Detection

机译：聚二乙炔比色检测战争气体，实现无设备检测

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Rationally designed polydiacetylene (PDA) molecules have been developed for rapid, selective, sensitive, and convenient colorimetric detection of orga-nophosphate (OP) nerve agents, a mass destruction weapon. Oxime (OX) functionality was incorporated into diacetylene molecules to utilize its strong affinity toward organophosphates. The diacetylene molecules having an OX functional group (OX-PDA) were self-assembled to form PDA liposomes in an aqueous solution. Upon exposure to organophosphate nerve agent simulants, OX at the OX-PDA liposome surface interacts with nerve agent simulants, which results in intraliposomal repulsive stress due to steric repulsion between OP-occupied OX units at the liposome surface as well as interli-posomal aggregation induced by increased hydrophobicity of the liposome surface via OP-OX complex formation. The resulting intra- and interliposomal stress causes disturbance of the conjugated backbone of OX-PDA, producing color change as a label-free and sensitive sensory signal. The effects of molecular structure on selectivity and sensitivity of OX-PDA liposome solution, OX-PDA liposome-embedded agarose gels, and OX-PDA liposome-coated cellulose acetate membranes were systematically investigated. The optimized OX-PDA liposome in the solid state showed selective and rapid optical transition upon exposure down to 160 ppb of diisopropylfluorophosphate (DFP), a nerve agent simulant. The results provide an insightful molecular design principle of PDA-based colorimetric sensor and suggest portable sensory patches for rapid, selective, sensitive, and convenient colorimetric detection of organophosphate nerve agents.
机译：已经开发出合理设计的聚二乙炔（PDA）分子，用于快速，选择性，灵敏和方便的比色法检测大规模杀伤性武器Orga-nophosphate（OP）神经毒剂。肟（OX）官能团被并入乙炔分子中，以利用其对有机磷酸酯的强亲和力。具有OX官能团的二乙炔分子（OX-PDA）在水溶液中自组装形成PDA脂质体。暴露于有机磷酸酯神经药模拟物后，OX-PDA脂质体表面的OX与神经药模拟物相互作用，由于脂质体表面OP占据的OX单元之间的空间排斥以及脂质体间诱导的聚集，导致脂质体内排斥应激通过OP-OX复合物形成增加脂质体表面的疏水性。产生的脂质体内和脂质间应力导致OX-PDA共轭骨架的干扰，产生颜色变化，作为无标记和敏感的感觉信号。系统地研究了分子结构对OX-PDA脂质体溶液，包埋OX-PDA脂质体的琼脂糖凝胶和OX-PDA脂质体包被的醋酸纤维素膜的选择性和灵敏度的影响。经过优化的固态OX-PDA脂质体在暴露于160 ppb的二异丙基氟磷酸盐（DFP）（一种神经刺激物模拟物）中时，表现出选择性和快速的光学转变。结果为基于PDA的比色传感器提供了有见地的分子设计原理，并为便携式，快速，选择性，灵敏和方便的比色法检测有机磷酸神经剂的感觉贴片提供了建议。

著录项

  • 来源
    《Advanced Functional Materials》 |2012年第8期|p.1632-1638|共7页
  • 作者

    Jiseok Lee; Sungbaek Seo; jinsang Kim;

  • 作者单位

    Macromolecular Science and Engineering University of Michigan 2300 Hayward St., Ann Arbor, Ml 48109-2136, USA;

    Macromolecular Science and Engineering University of Michigan 2300 Hayward St., Ann Arbor, Ml 48109-2136, USA;

    Macromolecular Science and Engineering Materials Science and Engineering Chemical Engineering Biomedical Engineering University of Michigan 2300 Hayward St., Ann Arbor, Ml 48109-2136, USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号