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首页> 外文期刊>Advanced Functional Materials >Antibacterial Surface Coatings from Zinc Oxide Nanoparticles Embedded in Poly(N-isopropylacrylamide) Hydrogel Surface Layers
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Antibacterial Surface Coatings from Zinc Oxide Nanoparticles Embedded in Poly(N-isopropylacrylamide) Hydrogel Surface Layers

机译：嵌入聚（N-异丙基丙烯酰胺）水凝胶表面层中的氧化锌纳米颗粒的抗菌表面涂层

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摘要

Despite multiple research approaches to prevent bacterial colonization on surfaces, device-associated infections are currently responsible for about 50% of nosocomial infections in Europe and significantly increase health care costs, which demands development of advanced antibacterial surface coatings. Here, novel antimicrobial composite materials incorporating zinc oxide nanoparticles (ZnO NP) into biocompatible poly(N-isopropylacryl-amide) (PNIPAAm) hydrogel layers are prepared by mixing the PNIPAAm prepolymer with ZnO NP, followed by spin-coating and photocrosslinking. Scanning electron microscopy (SEM) characterization of the composite film morphology reveals a homogeneous distribution of the ZnO NP throughout the film for every applied NP/polymer ratio. The optical properties of the embedded NP are not affected by the matrix as confirmed by UV-vis spectroscopy. The nanocomposite films exhibit bactericidal behavior towards Escherichia coll (E. coli) for a ZnO concentration as low as ≈0.74 μg cm~(-2) (1.33 mmol cm~(-3)), which is determined by inductively coupled plasma optical emission spectrometry. In contrast, the coatings are found to be non-cytotoxic towards a mammalian cell line (NIH/3T3) at bactericidal loadings of ZnO over an extended period of seven days. The differential toxicity of the ZnO/hydrogel nanocomposite thin films between bacterial and cellular species qualifies them as promising candidates for novel biomedical device coatings.
机译：尽管采取了多种研究方法来防止细菌在表面上定植，但与设备相关的感染目前仍占欧洲医院感染的50％，并显着增加了医疗保健成本，这需要开发先进的抗菌表面涂层。在这里，通过将PNIPAAm预聚物与ZnO NP混合，然后旋涂和光交联，制备了将氧化锌纳米颗粒（ZnO NP）掺入生物相容性聚（N-异丙基丙烯酰胺）（PNIPAAm）水凝胶层的新型抗菌复合材料。复合膜形态的扫描电子显微镜（SEM）表征显示，对于每个应用的NP /聚合物比率，ZnO NP在整个膜中均一分布。紫外可见光谱证实，嵌入的NP的光学特性不受基质的影响。纳米复合膜对ZnO浓度低至≈0.74μgcm〜（-2）（1.33 mmol cm〜（-3））时，表现出对大肠杆菌的杀菌行为，这是由电感耦合等离子体光发射法确定的光谱法。相反，发现该涂层在七天的延长时间内对ZnO的杀菌负荷下对哺乳动物细胞系（NIH / 3T3）无细胞毒性。细菌和细胞物种之间的ZnO /水凝胶纳米复合薄膜的差异毒性使它们有资格成为新型生物医学设备涂层的有希望的候选者。

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  • 来源
    《Advanced Functional Materials》 |2012年第11期|p.2376-2386|共11页
  • 作者

    Veronique B. Schwartz; Franck Thetiot; Sandra Ruetz; Sabine Puetz; Lars Choritz; Alexandros Lappas; Remote Foerch; Katharima Landfester; Ulrich Jonas;

  • 作者单位

    Max Planck Institute for Polymer Research Ackermannweg 10, 55122 Mainz, Germany;

    UMR CNRS 6521 Universite de Bretagne Occidentale 29285 Brest, France,Foundation for Research and Technology-Hellas (FORTH) Institute of Electronic Structure and Laser (IESL) Nikolaou Plastira 100, Vassilika Vouton, 71110 Heraklion, Greece;

    Max Planck Institute for Polymer Research Ackermannweg 10, 55122 Mainz, Germany;

    Max Planck Institute for Polymer Research Ackermannweg 10, 55122 Mainz, Germany;

    University Medical Center Mainz BiomaTiCS research group Department of Ophthalmology Langenbeckstrasse 1, 55131 Mainz, Germany;

    Foundation for Research and Technology-Hellas (FORTH) Institute of Electronic Structure and Laser (IESL) Nikolaou Plastira 100, Vassilika Vouton, 71110 Heraklion, Greece;

    Max Planck Institute for Polymer Research Ackermannweg 10, 55122 Mainz, Germany;

    Max Planck Institute for Polymer Research Ackermannweg 10, 55122 Mainz, Germany;

    Macromolecular Chemistry Department Chemistry and Biology University of Siegen Adolf-Reichwein-Strasse 2, 57076 Siegen, Germany,Foundation for Research and Technology-Hellas (FORTH) Bio-Organic Materials Chemistry Laboratory (BOMCLab) Nikolaou Plastira 100, Vassilika Vouton, 71110 Heraklion, Greece;

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