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Fabrication of Gelatin Microgels by a 'Cast' Strategy for Controlled Drug Release

机译：通过“可控”药物释放的“铸造”策略制备明胶微凝胶

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摘要

In this paper, we propose a "casting" strategy to prepare intrinsically fluorescent, uniform and porous gelatin microgels with multi-responsiveness. Gelatin microgels with tunable size were obtained by copying the structure of a porous CaCO_3 template. The diameter of the gelatin microgels was sensitive to salt concentration and pH. Doxorubicin and Rhodamine B as model drugs were loaded into the microgels via electrostatic interaction and release of the payload was triggered by changing the salt concentration and pH, respectively. Cell experiments demonstrated that the gelatin microgels had an excellent biocompatibility and biodegradability. The merits of gelatin microgels such as tunable size, biocompatibility, and stimulus responsive upload and release of positively charged small molecules will permit the microgels as excellent carriers for drug delivery. The whole manufacturing process is furthermore environmental-friendly involving no organic solvents and surfactants.
机译：在本文中，我们提出了一种“浇铸”策略，以制备具有多响应性的内在荧光，均匀且多孔的明胶微凝胶。通过复制多孔CaCO_3模板的结构获得具有可调大小的明胶微凝胶。明胶微凝胶的直径对盐浓度和pH敏感。通过静电相互作用将阿霉素和罗丹明B作为模型药物加载到微凝胶中，并分别通过更改盐浓度和pH来触发有效负载的释放。细胞实验证明明胶微凝胶具有优异的生物相容性和生物降解性。明胶微凝胶的优点，如可调大小，生物相容性以及带正电荷的小分子的刺激响应上载和释放，将使这些微凝胶成为药物输送的极佳载体。此外，整个制造过程对环境友好，不涉及有机溶剂和表面活性剂。

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  • 来源
    《Advanced Functional Materials》 |2012年第13期|p.2673-2681|共9页
  • 作者

    Anhe Wang; Yue Cui; Junbai Li; Jan C. M. van Hest;

  • 作者单位

    Institute for Molecules and Materials Radboud University Nijmegen Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands;

    Key Lab of Colloid and Interface Sciences Institute of Chemistry Chinese Academy of Sciences Zhong Guan Cun, Bei Yi Jie 2, Beijing 100190, China;

    Key Lab of Colloid and Interface Sciences Institute of Chemistry Chinese Academy of Sciences Zhong Guan Cun, Bei Yi Jie 2, Beijing 100190, China;

    Institute for Molecules and Materials Radboud University Nijmegen Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands;

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