A Versatile Synthetic Platform for a Wide Range of Functionalized Biomaterials

Zhengwei You; Yadong Wang

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A Versatile Synthetic Platform for a Wide Range of Functionalized Biomaterials

机译：多种功能化生物材料的多功能合成平台

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The introduction of functionalities to synthetic biomaterials represents a major direction and a significant challenge in biomedical engineering. A synthetic platform using novel acid-induced epoxide ring-opening polymerization promoted by a newly designed catalyst to produce a variety of biodegradable and functionalized biomaterials is reported. The polymerization proceeds smoothly in the presence of functional groups including alkenyl, aromatic, ether, ester, and free hydroxyl groups. The functionalities of the resultant biomaterials can be further enriched using many post-functionalization methods. This platform yields biomaterials with a wide range of hydrophilicity, crystal-linity, charge, mechanical properties, and cell interactions. This platform for functionalized biomaterials is simple, versatile, and can be easily adapted to specific cell types and tissues of interest.

机译：在合成生物材料中引入功能性是生物医学工程学的主要方向和重大挑战。报道了一种使用新型酸诱导的环氧化物开环聚合反应的合成平台，该反应是通过新设计的催化剂促进的，以生产各种可生物降解和功能化的生物材料。在包含烯基，芳族，醚，酯和游离羟基的官能团的存在下，聚合反应顺利进行。使用许多后功能化方法可以进一步丰富所得生物材料的功能。该平台生产出具有广泛亲水性，结晶度，电荷，机械性能和细胞相互作用的生物材料。这个用于功能化生物材料的平台简单，通用，并且可以轻松地适应特定的细胞类型和目标组织。

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《Advanced Functional Materials》 |2012年第13期|p.2812-2820|共9页
作者
Zhengwei You; Yadong Wang;
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Departments of Bioengineering and Surgery and the McGowan Institute University of Pittsburgh 3700 O'Hara Street, Pittsburgh, PA 15261, USA;

Departments of Bioengineering and Surgery and the McGowan Institute University of Pittsburgh 3700 O'Hara Street, Pittsburgh, PA 15261, USA;

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A Versatile Synthetic Platform for a Wide Range of Functionalized Biomaterials

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