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Fabrication of Responsive, Softening Neural Interfaces

机译:响应性软化神经接口的制造

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摘要

A novel processing method is described using photolithography to pattern thin-film flexible electronics on shape memory polymer substrates with mechanical properties tailored to improve biocompatability and enhance adhesion between the polymer substrate and metal layers. Standard semiconductor wafer processing techniques are adapted to enable robust device design onto a variety of softening substrates with tunable moduli. The resulting devices are stiff enough (shear modulus of ≈700 MPa) to assist with device implantation and then soften in vivo (≈ 300 kPa) approaching the modulus of brain tissue (≈10 kPa) within 24 h. Acute in vivo studies demonstrate that these materials are capable of recording neural activity. Softening multi-electrode arrays offer a highly customizable interface, which can be optimized to improve biocompatibility, enabling the development of robust, reliable neural electrodes for neural engineering and neuroscience.
机译:描述了一种新颖的处理方法,该方法使用光刻技术在形状记忆聚合物基板上对薄膜柔性电子器件进行构图,其机械性能经过定制以改善生物相容性并增强聚合物基板与金属层之间的粘合力。标准的半导体晶片加工技术适于使鲁棒的器件设计能够在具有可调模数的各种软化基板上进行。产生的设备足够坚硬(剪切模量约为700 MPa)以协助设备植入,然后在24小时内在体内软化(约300 kPa),达到脑组织模量(约10 kPa)。急性体内研究表明,这些材料能够记录神经活动。软化的多电极阵列提供了高度可定制的界面,可以对其进行优化以改善生物相容性,从而能够开发出用于神经工程和神经科学的坚固,可靠的神经电极。

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  • 来源
    《Advanced Functional Materials》 |2012年第16期|p.3470-3479|共10页
  • 作者单位

    Department of Materials Science and Engineering The University of Texas at Dallas 800 West Campbell RD, Mailstop RL 10, Richardson, TX 75080, USA;

    Department of Materials Science and Engineering The University of Texas at Dallas 800 West Campbell RD, Mailstop RL 10, Richardson, TX 75080, USA;

    Department of Materials Science and Engineering The University of Texas at Dallas 800 West Campbell RD, Mailstop RL 10, Richardson, TX 75080, USA;

    Department of Mechanical Engineering The University of Texas at Dallas 800 West Campbell RD, Mailstop RL 10, Richardson, TX 75080, USA;

    School of Behavioral and Brain Sciences Erikjonnson School of Engineering The University of Texas at Dallas 800 West Campbell RD, Mailstop RL 10, Richardson, TX 75080, USA;

    Plexon Inc., 6500 Greenville Ave., Suite 730, Dallas, TX 75206, USA;

    Department of Materials Science and Engineering The University of Texas at Dallas 800 West Campbell RD, Mailstop RL 10, Richardson, TX 75080, USA,Department of Mechanical Engineering The University of Texas at Dallas 800 West Campbell RD, Mailstop RL 10, Richardson, TX 75080, USA;

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