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首页> 外文期刊>Advanced Functional Materials >Discoidal Porous Silicon Particles: Fabrication and Biodistribution in Breast Cancer Bearing Mice
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Discoidal Porous Silicon Particles: Fabrication and Biodistribution in Breast Cancer Bearing Mice

机译：盘状多孔硅颗粒：乳腺癌小鼠的制备和生物分布。

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摘要

Porous silicon (pSi) is emerging as a promising material in the development of nanovectors for the systemic delivery of therapeutic and imaging agents. The integration of photolithographic patterning, typical of the semiconductor industry, with electrochemical silicon etching provides a highly flexible strategy to fabricate monodisperse and precisely tailored nanovectors. Here, a microfabrication strategy for direct lithographic patterning of discoidal pSi particles is presented that enables precise and independent control over particle size, shape, and porous structure. Discoidal pSi nanovectors with diameters ranging from 500 to 2600 nm, heights from 200 to 700 nm, pore sizes from 5 to 150 nm, and porosities from 40 to 90% are demonstrated. The degradation in serum, interaction with immune and endothelial cells in vitro, and biodistribution in mice bearing breast tumors are assessed for two discoidal nanovectors with sizes of 600 nm × 400 nm and 1000 nm × 400 nm. It is shown that both particle types are degraded after 24 h of continuous gentle agitation in serum, do not stimulate cytokine release from macrophages or affect endothelial cell viability, and accumulate up to about 10% of the injected dose per gram tissue in orthotopic murine models of breast cancer. The accumulation of the discoidal pSi nanovectors into the breast tumor mass is found to be up to five times higher than for spherical silica beads with similar diameters.
机译：多孔硅（pSi）在开发用于系统递送治疗剂和成像剂的纳米载体方面正成为一种有前途的材料。半导体工业中典型的光刻图案与电化学硅蚀刻的集成提供了一种高度灵活的策略来制造单分散和精确定制的纳米载体。在此，提出了一种用于直接盘状pSi颗粒的光刻图案化的微细加工策略，该策略能够精确，独立地控制粒度，形状和多孔结构。盘状pSi纳米载体的直径范围为500至2600 nm，高度为200至700 nm，孔径为5至150 nm，孔隙率为40％至90％。针对两个大小分别为600 nm×400 nm和1000 nm×400 nm的盘状纳米载体，评估了血清降解，体外与免疫细胞和内皮细胞的相互作用以及荷瘤小鼠的生物分布。结果表明，在血清中连续轻柔地搅动24小时后，两种颗粒类型均被降解，不刺激巨噬细胞释放细胞因子或影响内皮细胞生存力，并且在原位鼠模型中每克组织累积至多约10％的注射剂量。乳腺癌。发现盘状pSi纳米载体在乳腺肿瘤块中的积累比具有类似直径的球形二氧化硅珠粒高多达五倍。

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  • 来源
    《Advanced Functional Materials》 |2012年第20期|p.4225-4235|共11页
  • 作者

    Biana Godin; Ciro Chiappini; Srimeenakshi Srinivasan; Jenolyn F. Alexander; Kenji Yokoi; Mauro Ferrari; Paolo Decuzzi; Xuewu Liu;

  • 作者单位

    Department of Nanomedicine The Methodist Hospital Research Institute 6670 Bertner Ave, Houston, TX 77030, USA;

    Department of Nanomedicine The Methodist Hospital Research Institute 6670 Bertner Ave, Houston, TX 77030, USA;

    Department of Nanomedicine The Methodist Hospital Research Institute 6670 Bertner Ave, Houston, TX 77030, USA;

    Department of Nanomedicine The Methodist Hospital Research Institute 6670 Bertner Ave, Houston, TX 77030, USA;

    Department of Nanomedicine The Methodist Hospital Research Institute 6670 Bertner Ave, Houston, TX 77030, USA;

    Department of Nanomedicine The Methodist Hospital Research Institute 6670 Bertner Ave, Houston, TX 77030, USA;

    Department of Nanomedicine The Methodist Hospital Research Institute 6670 Bertner Ave, Houston, TX 77030, USA;

    Department of Nanomedicine The Methodist Hospital Research Institute 6670 Bertner Ave, Houston, TX 77030, USA;

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