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首页> 外文期刊>Advanced Functional Materials >A Multifuntional Nanoplatform Based on Responsive Fluorescent Plasmonic ZnO-Au@PEC Hybrid Nanogels
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A Multifuntional Nanoplatform Based on Responsive Fluorescent Plasmonic ZnO-Au@PEC Hybrid Nanogels

机译：基于响应性荧光等离子体ZnO-Au @ PEC杂化纳米凝胶的多功能纳米平台

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摘要

Under a rational design, combining multiple constituents into a single nano-object will not only bridge the unique properties of individual materials to leverage research both fundamentally and practically, but will also improve conventional sensing, imaging, and therapeutic efficacies. Such a nano-object (100 nm) can be constructed by covalently bonding ZnO quantum dots (QDs) to nonlinear poly(ethylene glycol)-based nanogel network chains, followed by appropriate growth of metallic Au. With the polymer gel network serving as a three-dimensional scaffold, the fluorescence of ZnO QDs can be well protected, while metal Au still retains its surface plasmon resonance property. The ZnO QDs covalently bonded to the thermo-responsive gel network chains can sensitively respond to temperature change of the surrounding fluids over the physiologically important range of 37-42 °C, converting the disruptions in homeostasis of local temperature into stable, robust and high-resolution fluorescent signals. The thermoresponsive hybrid nanogels can not only enter into and light up B16F10 cells, but also regulate the release of a model anticancer drug, temozolomide, in response to either local environmental temperature change or external near-infrared light-induced localized hyperthermia from metal Au. The combined chemo-photothermal therapy can significantly improve the therapeutic efficacy due to a synergistic effect.
机译：在合理的设计下，将多种成分组合到一个纳米物体中，不仅可以桥接单个材料的独特特性，从而从根本上和实践上充分利用研究成果，而且还将改善常规的传感，成像和治疗功效。可以通过将ZnO量子点（QD）共价键合到基于非线性聚（乙二醇）的纳米凝胶网络链上，然后适当生长金属Au来构造这样的纳米物体（100 nm）。使用聚合物凝胶网络作为三维支架，可以很好地保护ZnO QD的荧光，而金属Au仍然保留其表面等离子体共振特性。共价键合到热响应性凝胶网络链上的ZnO QD可以在生理上重要的37-42°C范围内敏感地响应周围流体的温度变化，从而将局部温度的稳态破坏转变为稳定，坚固和高-分辨率荧光信号。热响应性混合纳米凝胶不仅可以进入B16F10细胞并使其发光，而且还可以调节模型抗癌药物替莫唑胺的释放，以响应局部环境温度变化或金属金的外部近红外光诱导的局部高温。由于协同作用，化学-光热疗法的组合可以显着提高治疗效果。

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  • 来源
    《Advanced Functional Materials》 |2011年第15期|p.2830-2839|共10页
  • 作者

    Weitai Wu; Jing Shen; Probal Banerjee; Shuiqin Zhou;

  • 作者单位

    Department of Chemistry College of Staten Island of The City University of New York Staten Island, New York 10314, USA;

    Department of Chemistry College of Staten Island of The City University of New York Staten Island, New York 10314, USA;

    Department of Chemistry and CSI/IBR Center for Developmental Neuroscience College of Staten Island of The City University of New York Staten Island, New York 10314, USA;

    Department of Chemistry College of Staten Island of The City University of New York Staten Island, New York 10314, USA;

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