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首页> 外文期刊>Advanced materials for optics and electronics >Epoxy Ring Opening Phase Transfer as a General Route to Water Dispersible Superparamagnetic Fe_3O_4 Nanoparticles and Their Application as Positive MRI Contrast Agents
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Epoxy Ring Opening Phase Transfer as a General Route to Water Dispersible Superparamagnetic Fe_3O_4 Nanoparticles and Their Application as Positive MRI Contrast Agents

机译：环氧开环相转移作为水可分散的超顺磁性Fe_3O_4纳米粒子的一般途径及其在MRI造影剂中的应用

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摘要

A novel and efficient method to produce water dispersible superparamagnetic Fe_3O_4 nanoparticles is described. Nanoparticles prepared by non-hydrolytic organic phase methods are subsequently functionalized with (3-glycidyloxy-propyl)trimethoxysilane, a linker that prevents aggregation and is available for subsequent coupling reactions with a wide range of polymers and biomole-cules. Ring opening coupling reactions were used to coat the epoxy-function-alized magnetite nanoparticles with aminated polymers (polyetheramines) or small molecules (arginine). The resulting nanoparticles, with hydrodynamic size of 13 nm, are found to be very stable over extended periods in water or PBS due to the presence of a dense stabilizer layer covalently anchored to the surface. Exceptionally high spin-lattice relaxivity, r_1, values of 17 s~(-1) mM~(-1), and low r2/r_1 ratios of 3.3-3.8 were exhibited in the clinical MRI frequency range, irrespective of the molecule selected for nanoparticle stabilization. As a result the dispersions are excellent candidates for incorporation into multifunctional assemblies or for use as positive contrast agent for MRI.
机译：描述了一种新颖且有效的制备水分散性超顺磁性Fe_3O_4纳米粒子的方法。通过非水解有机相方法制备的纳米粒子随后被（3-环氧丙氧基-丙基）三甲氧基硅烷官能化，这是一种防止聚集的接头，可用于随后与多种聚合物和生物分子的偶联反应。开环偶联反应用于用胺化聚合物（聚醚胺）或小分子（精氨酸）涂覆环氧官能化的磁铁矿纳米颗粒。由于存在共价锚定在表面上的致密稳定剂层，因此发现在水或PBS中，具有13 nm流体力学尺寸的所得纳米颗粒在延长的时间内非常稳定。在临床MRI频率范围内，无论选择哪种分子，都具有极高的自旋晶格弛豫度r_1、17 s〜（-1）mM〜（-1）和低r2 / r_1比值3.3-3.8。纳米粒子稳定化。结果，该分散体是结合到多功能组件中或用作MRI的阳性造影剂的极佳候选者。

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  • 来源
    《Advanced materials for optics and electronics》 |2011年第24期|p.4769-4775|共7页
  • 作者

    Tsedev Ninjbadgar; Dermot F. Brougham;

  • 作者单位

    National Institute for Cellular Biotechnology School of Chemical Sciences Dublin City University Glasnevin, Dublin 9, Ireland;

    National Institute for Cellular Biotechnology School of Chemical Sciences Dublin City University Glasnevin, Dublin 9, Ireland;

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