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首页> 外文期刊>Advanced Functional Materials >Capsosomes with MuItilayered Subcompartments: Assembly and Loading with Hydrophobic Cargo
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Capsosomes with MuItilayered Subcompartments: Assembly and Loading with Hydrophobic Cargo

机译：具有多层子隔室的脂质体：疏水性货物的组装和装载

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摘要

Therapeutic artificial cells or organelles are nanoengineered vehicles that are expected to substitute for missing or lost cellular function. The creation of capsosomes, polymer carrier capsules containing liposomal subcompartments, is a promising approach towards constructing such therapeutic devices using the layer-by-layer assembly method. Herein, the assembly of intact, nonaggregated capsosomes containing multiple liposome layers is reported. It is also further demonstrated that thiocoraline, a hydrophobic model peptide with antitumor activity, can be efficiently loaded into the membrane of the liposomal subcompartments of the capsosomes. Cell viability assays verify the activity of the trapped antitumor cargo. It is also shown that pristine capsosomes do not display inherent cytotoxic effects. The ability to tune the number of liposome layers and hence the drug loading in capsosomes as well as their noncytotoxicity provide new opportunities for the creation of therapeutic artificial cells and organelles.
机译：治疗性人工细胞或细胞器是纳米工程载体，有望替代缺失或丧失的细胞功能。脂质体，即含有脂质体小室的聚合物载体胶囊，是一种使用逐层组装方法构建这种治疗装置的有前途的方法。在此，报道了包含多个脂质体层的完整的，非聚集的脂质体的组装。还进一步证明了具有抗肿瘤活性的疏水性模型肽硫代可可林可有效地加载到脂质体脂质体小室的膜中。细胞活力测定证实了被捕获的抗肿瘤药物的活性。还显示原始的脂质体不显示固有的细胞毒性作用。调节脂质体层数的能力以及由此在脂质体中的载药量及其无细胞毒性为创建治疗性人工细胞和细胞器提供了新的机会。

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  • 来源
    《Advanced Functional Materials》 |2010年第1期|59-66|共8页
  • 作者

    Leticia Hosta-Rigau; Brigitte Staedler; Yan Yan; Edouard Collins Nice; Joan K. Heath; Fernando Albericio; Frank Caruso;

  • 作者单位

    Institute for Research in Biomedicine Barcelona Science Park CIBER-BBN, Networking Centre on Bioengineering Biomaterials and Nanomedicine Baldiri Reixac 10-12 08028-Barcelona (Spain) Department of Organic Chemistry University of Barcelona Marti Franques 1, 08028-Barcelona (Spain);

    rnCentre for Nanoscience and Nanotechnology (CNST) Department of Chemical and Biomolecular Engineering The University of Melbourne Parkville, Victoria 3010 (Australia);

    rnCentre for Nanoscience and Nanotechnology (CNST) Department of Chemical and Biomolecular Engineering The University of Melbourne Parkville, Victoria 3010 (Australia);

    rnLudwig Institute for Cancer Research Royal Melbourne Hospital PO Box 2008, Parkville, Victoria 3050 (Australia);

    rnLudwig Institute for Cancer Research Royal Melbourne Hospital PO Box 2008, Parkville, Victoria 3050 (Australia);

    rnInstitute for Research in Biomedicine Barcelona Science Park CIBER-BBN, Networking Centre on Bioengineering Biomaterials and Nanomedicine Baldiri Reixac 10-12 08028-Barcelona (Spain) Department of Organic Chemistry University of Barcelona Marti Franques 1, 08028-Barcelona (Spain);

    rnCentre for Nanoscience and Nanotechnology (CNST) Department of Chemical and Biomolecular Engineering The University of Melbourne Parkville, Victoria 3010 (Australia);

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