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首页> 外文期刊>Advanced Functional Materials >Stem Cell Aligned Growth Induced by CeO_2 Nanoparticles in PLGA Scaffolds with Improved Bioactivity for Regenerative Medicine
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Stem Cell Aligned Growth Induced by CeO_2 Nanoparticles in PLGA Scaffolds with Improved Bioactivity for Regenerative Medicine

机译：CeO_2纳米颗粒在PLGA支架中诱导干细胞排列的生长，具有再生生物活性。

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摘要

Hybrid 2D polymeric-ceramic biosupports are fabricated by mixing a nanostructured CeO_2 powder with 85:15 poly(D,L-lactic-co-glycolic acid) (PLGA)/dichloromethane solutions at specific concentrations, followed by solvent casting onto pre-patterned molds. The mold patterning allows the orientation of ceramic nanoparticles into parallel lines within the composite scaffold. The ability of the produced films to host and address cell growth is evaluated after 1, 3, and 6 days of culturing with murine derived cardiac and mesenchymal stem cells (CSCs and MSCs), and compared with PLCA films without ceramics and loaded with nanostructured TiO_2. Aligned cell growth is observed only for scaffolds that incorporate oriented ceramic nanoparticles, attributed to the nanoceramic ability to modulate the roughness pitch, thus improving cell sensitivity towards the host surface features. Better CSC and MSC proliferative activity is observed for CeO_2 composites with respect to either TiO_2-added or unfilled PLCA films. This evidence may be related to the nanostructured CeO_2 antioxidative properties.
机译：通过将纳米结构的CeO_2粉末与特定浓度的85:15聚（D，L-乳酸-乙醇酸共聚物）（PLGA）/二氯甲烷溶液混合，然后将溶剂浇铸到预先成型的模具上，来制造2D混合聚合物陶瓷生物载体。模具构图允许陶瓷纳米颗粒在复合支架内定向成平行线。在用鼠源性心脏和间充质干细胞（CSC和MSC）培养1天，3天和6天后，评估了产生的膜容纳和处理细胞生长的能力，并将其与不带陶瓷并装有纳米结构TiO_2的PLCA膜进行了比较。 。仅在掺入定向陶瓷纳米颗粒的支架中观察到对齐的细胞生长，这归因于纳米陶瓷调节粗糙度间距的能力，从而提高了细胞对宿主表面特征的敏感性。相对于添加TiO_2或未填充的PLCA膜，CeO_2复合材料具有更好的CSC和MSC增殖活性。该证据可能与纳米结构的CeO_2抗氧化性能有关。

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  • 来源
    《Advanced Functional Materials》 |2010年第10期|P.1617-1624|共8页
  • 作者

    Corrado Mandoli; Francesco Pagliari; Stefania Pagliari; Ciancarlo Forte; Paolo Di Nardo; Silvia Licoccia; Enrico Traversa;

  • 作者单位

    International Research Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Tsukuba, Ibaraki 305-0044 (Japan);

    rnLaboratorio di Cardiologia Molecolare e Cellulare Dipartimento di Medicina Interna University of Rome Tor Vergata 00133 Roma (Italy);

    rnLaboratorio di Cardiologia Molecolare e Cellulare Dipartimento di Medicina Interna University of Rome Tor Vergata 00133 Roma (Italy);

    rnLaboratorio di Cardiologia Molecolare e Cellulare Dipartimento di Medicina Interna University of Rome Tor Vergata 00133 Roma (Italy);

    rnLaboratorio di Cardiologia Molecolare e Cellulare Dipartimento di Medicina Interna University of Rome Tor Vergata 00133 Roma (Italy);

    rnNAST Center &. Dipartimento di Scienze e Tecnologie Chimiche University of Rome Tor Vergata 00133 Roma (Italy);

    rnInternational Research Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Tsukuba, Ibaraki 305-0044 (Japan) NAST Center &. Dipartimento di Scienze e Tecnologie Chimiche University of Rome Tor Vergata 00133 Roma (Italy);

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