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首页> 外文期刊>Advanced Functional Materials >Fabrication of Density Gradients of Biodegradable Polymer Micropartides and Their Use in Guiding Neurite Outgrowth
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Fabrication of Density Gradients of Biodegradable Polymer Micropartides and Their Use in Guiding Neurite Outgrowth

机译：可生物降解聚合物微粒的密度梯度的制备及其在指导神经突生长中的应用

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摘要

A new method for generating both continuous and discrete density gradients in micropartides of biodegradable polymers via an electrospray technique is reported. The gradients are generated by spatially varying the deposition time of electrosprayed micropartides. The substrate coated with a density gradient of micropartides has varying surface roughness, offering a unique system for studying the effect of physical cues on neurite outgrowth from dorsal root ganglia. An optimal surface roughness for promoting neuron adhesion and neurite extension in vitro is obtained. Furthermore, this capability of approach is extended to generate a gradient of fluorescein isothiocyanate labeled bovine serum albumin by encapsulating it in the polymer micropartides in situ during electrospray. Taken together, this new class of substrates with gradients of microparticle density can potentially be used in various biomedical applications such as neural tissue engineering.
机译：报道了一种通过电喷雾技术在可生物降解聚合物的微粒中产生连续和离散密度梯度的新方法。通过在空间上改变电喷涂微粒的沉积时间来生成梯度。涂有微粒密度梯度的基材具有变化的表面粗糙度，为研究物理线索对背根神经节神经突生长的影响提供了独特的系统。获得了在体外促进神经元粘附和神经突延伸的最佳表面粗糙度。此外，通过在电喷雾过程中将其封装在聚合物微粒中，扩展了这种方法的能力以生成荧光素异硫氰酸酯标记的牛血清白蛋白的梯度。综上所述，这种新型的具有微粒密度梯度的基质可以潜在地用于各种生物医学应用，例如神经组织工程。

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  • 来源
    《Advanced Functional Materials》 |2010年第10期|P.1632-1637|共6页
  • 作者

    Xiaoran Li; Matthew R. MacEwan; Jingwei Xie; Daku Siewe; Xiaoyan Yuan; Younan Xia;

  • 作者单位

    Department of Biomedical Engineering Washington University St. Louis, MO 63130 (USA) School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Tianjin University Tianjin 300072 (P. R. China);

    rnDepartment of Biomedical Engineering Washington University St. Louis, MO 63130 (USA);

    rnDepartment of Biomedical Engineering Washington University St. Louis, MO 63130 (USA);

    rnDepartment of Biomedical Engineering Washington University St. Louis, MO 63130 (USA);

    rnSchool of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Tianjin University Tianjin 300072 (P. R. China);

    rnDepartment of Biomedical Engineering Washington University St. Louis, MO 63130 (USA);

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