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Hollow Mesoporous Zirconia Nanocapsules for Drug Delivery

机译：空心中孔氧化锆纳米胶囊用于药物输送

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摘要

Hollow mesoporous zirconia nanocapsules (hm-ZrO_2) with a hollow core/ porous shell structure are demonstrated as effective vehicles for anti-cancer drug delivery. While the highly porous feature of the shell allows the drug, doxorubicin(DOX), to easily pass through between the inner void space and surrounding environment of the particles, the void space in the core endows the nanocapsules with high drug loading capacity. The larger the inner hollow diameter, the higher their DOX loading capacity. A loading of 102% related to the weight of hm-ZrO_2 is achieved by the nanocapsules with an inner diameter of 385 nm. Due to their pH-dependent charge nature, hm-ZrO_2 loaded DOX exhibit pH-dependent drug releasing kinetics. A lower pH offers a faster DOX release rate from hm-ZrO_2. Such a property makes the loaded DOX easily release from the nanocapsules when up-taken by living cells. Although the flow cytometry reveals more uptake of hm-ZrO_2 particles by normal cells, hm-ZrO_2 loaded DOX release more drugs in cancer cells than in normal cells, leading to more cytotoxicity toward tumor cells and less cytotoxicity to healthy cells than free DOX.
机译：具有空心核/多孔壳结构的空心介孔氧化锆纳米胶囊（hm-ZrO_2）被证明是有效的抗癌载体。尽管壳的高度多孔性使药物阿霉素（DOX）能够轻松穿过颗粒的内部空隙空间和周围环境，但核心中的空隙空间使纳米胶囊具有较高的载药量。内部空心直径越大，其DOX负载能力越高。通过具有385nm内径的纳米胶囊实现了与hm-ZrO_2的重量有关的102％的负载。由于它们的pH依赖性电荷性质，负载hm-ZrO_2的DOX表现出pH依赖性药物释放动力学。较低的pH值可从hm-ZrO_2释放更快的DOX。这样的性质使得当被活细胞摄取时，负载的DOX容易从纳米胶囊释放。尽管流式细胞仪显示正常细胞摄取更多的hm-ZrO_2颗粒，但是载有hm-ZrO_2的DOX在癌细胞中释放的药物要比正常细胞释放更多，与游离DOX相比，对肿瘤细胞的细胞毒性更大，对健康细胞的细胞毒性更低。

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  • 来源
    《Advanced Functional Materials》 |2010年第15期|P.2442-2447|共6页
  • 作者

    Shaoheng Tang; rnXiaoqing Huang; rnXiaolan Chen; rnNanfeng Zheng;

  • 作者单位

    State Key Laboratory for Physical Chemistry of Solid Surfaces and Department of Chemistry College of Chemistry and Chemical Engineering, Xiamen University Xiamen 361005 (China);

    rnState Key Laboratory for Physical Chemistry of Solid Surfaces and Department of Chemistry College of Chemistry and Chemical Engineering, Xiamen University Xiamen 361005 (China);

    rnState Key Laboratory for Physical Chemistry of Solid Surfaces and Department of Chemistry College of Chemistry and Chemical Engineering, Xiamen University Xiamen 361005 (China);

    rnState Key Laboratory for Physical Chemistry of Solid Surfaces and Department of Chemistry College of Chemistry and Chemical Engineering, Xiamen University Xiamen 361005 (China);

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