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首页> 外文期刊>Advanced Functional Materials >Squaraine-Doped Functional Nanoprobes: Lipophilically Protected Near-Infrared Fluorescence for Bioimaging
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Squaraine-Doped Functional Nanoprobes: Lipophilically Protected Near-Infrared Fluorescence for Bioimaging

机译：掺杂方胺的功能性纳米探针：亲脂保护的近红外荧光生物成像。

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摘要

Hydrophobically stabilized near-IR fluorescence from self-assembled nanoprobes composed of amphiphilic poly(maleic anhydride-alt-octadec-1-ene) (PMAO) and lipophilized squaraine dopants is reported. From comparative studies with varying lipophilicity of squaraine dyes as well as of nanopar-ticulate polymer matrices, it is found that dual protection by simultaneous lipophilization of the dye-polymer pair greatly improves the chemical stability of labile squaraine dyes, to produce efficient NIR fluorescence in physiological aqueous milieux. The surface properties of negatively charged PMAO nanoparticles are readily modified by coating with an amine-rich cationic glycol chitosan with biofunctionality. Efficient cellular imaging and in vivo sentinel lymph node mapping with size and surface-controlled nanoprobes demonstrate that lipophilic dual protection of NIR fluorescence and the underlying functional nanoprobe approach hold great potential for bioimaging applications.
机译：报道了由两亲性聚（马来酸酐-alt-十八烷基-1-烯）（PMAO）和亲脂性方酸掺杂剂组成的自组装纳米探针的疏水稳定近红外荧光。通过对方酸染料和纳米颗粒状聚合物基质不同亲脂性的比较研究发现，通过同时进行亲脂性染料-聚合物对的双重保护，可大大提高不稳定方酸染料的化学稳定性，从而在硅胶中产生有效的NIR荧光。生理性水环境。带负电荷的PMAO纳米颗粒的表面性质可以通过用具有生物功能的富胺阳离子乙二醇壳聚糖包被而容易地改性。高效的细胞成像和体内前哨淋巴结定位以及大小可控的纳米探针表明，NIR荧光的亲脂性双重保护和潜在的功能性纳米探针方法在生物成像应用中具有巨大的潜力。

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  • 来源
    《Advanced Functional Materials》 |2010年第17期|P.2786-2793|共8页
  • 作者

    Yong-Deok Lee; Chang-Keun Lim; Sehoon Kim; Ick Chan Kwon; Jungahn Kim;

  • 作者单位

    Biomedical Science Center Korea Institute of Science and Technology 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea) Department of Chemistry Kyung Hee University Seoul 130-701 (Korea);

    rnBiomedical Science Center Korea Institute of Science and Technology 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea);

    rnBiomedical Science Center Korea Institute of Science and Technology 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea);

    rnBiomedical Science Center Korea Institute of Science and Technology 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea);

    Department of Chemistry Kyung Hee University Seoul 130-701 (Korea);

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