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首页> 外文期刊>Advanced Functional Materials >Selective Zinc(Ⅱ)-lon Fluorescence Sensing By A Functionalized Mesoporous Material Covalently Grafted With A Fluorescent Chromophore And Consequent Biological Applications
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Selective Zinc(Ⅱ)-lon Fluorescence Sensing By A Functionalized Mesoporous Material Covalently Grafted With A Fluorescent Chromophore And Consequent Biological Applications

机译：共价接枝荧光发色团的功能化介孔材料的选择性锌（Ⅱ）-lon荧光传感及其生物学应用

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A highly ordered 2D-hexagonal mesoporous silica material is functionalized with 3-aminopropyltriethoxysilane. This organically modified mesoporous material is grafted with a dialdehyde fluorescent chromophore, 4-methyl-2,6-diformyl phenol. Powder X-ray diffraction, transmission electron microscopy, N_2 sorption, Fourier transform infrared spectroscopy, and UV-visible absorption and emission have been employed to characterize the material. This material shows excellent selective Zn~(2+) sensing, which is due to the fluorophore moiety present at its surface. Fluorescence measurements reveal that the emission intensity of the Zn~(2+) -bound mesoporous material increases significantly upon addition of various concentrations of Zn~(2+) , while the introduction of other biologically relevant (Ca~(2+), Mg~(2+), Na~+, and K~+) and environmentally hazardous transition-metal ions results in either unchanged or weakened intensity. The enhancement of fluorescence is attributed to the strong covalent binding of Zn~(2+), evident from the large binding constant value (0.87 × 10~4 M~(-1)). Thus, this functionalized mesoporous material grafted with the fluorescent chromophore could monitor or recognize Zn~(2+) from a mixture of ions that contains Zn~(2+) even in trace amounts and can be considered as a selective fluorescent probe. We have examined the application of this mesoporous zinc(II) sensor to cultured living cells (A375 human melanoma and human cervical cancer cell, HeLa) by fluorescence microscopy.
机译：用3-氨丙基三乙氧基硅烷对高度有序的2D-六方介孔二氧化硅材料进行功能化。该有机改性的介孔材料接枝有二醛荧光发色团4-甲基-2,6-二甲酰基苯酚。粉末X射线衍射，透射电子显微镜，N_2吸附，傅里叶变换红外光谱和UV-可见光吸收和发射已用于表征材料。该材料显示出出色的选择性Zn〜（2+）感测，这是由于其表面存在荧光团部分所致。荧光测量表明，加入各种浓度的Zn〜（2+）并引入其他生物学相关的Ca〜（2 +），Mg时，结合Zn〜（2+）的中孔材料的发射强度显着增加。 〜（2 +），Na〜+和K〜+）和对环境有害的过渡金属离子会导致强度不变或减弱。荧光的增强归因于Zn〜（2+）的强共价结合，从大的结合常数（0.87×10〜4 M〜（-1））可以看出。因此，这种接枝有荧光发色团的功能化介孔材料甚至可以从痕量的含Zn〜（2+）的离子混合物中监测或识别Zn〜（2+），可以被视为选择性荧光探针。我们已经通过荧光显微镜检查了这种介孔锌（II）传感器在培养的活细胞（A375人黑素瘤和人宫颈癌细胞HeLa）中的应用。

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