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Design And Fabrication Of Magnetically Functionalized Core/shell Microspheres For Smart Drug Delivery

机译：磁性功能化核/壳微球用于智能药物递送的设计和制造

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摘要

The fabrication of magnetically functionalized core/shell microspheres by using the microfluidic flow-focusing (MFF) approach is reported. The shell of each microsphere is embedded with magnetic nanoparticles, thereby enabling the microspheres to deform under an applied magnetic field. By encapsulating a drug, for example, aspirin, inside the microspheres, the drug release of the microspheres is enhanced under the compression-extension oscillations that are induced by an AC magnetic field. This active pumping mode of drug release can be controlled by varying the frequency and magnitude of the applied magnetic field as well as the time profile of the magnetic field. UV absorption measurements of cumulative aspirin release are carried out to determine the influence of these factors. The drug release behavior is found to be significantly different depending on whether the applied field varies sinusoidally or in a step-function manner with time.
机译：报道了通过使用微流体流聚焦（MFF）方法制造的磁性功能化的核/壳微球。每个微球的外壳都嵌入了磁性纳米粒子，从而使微球在施加的磁场下变形。通过将药物例如阿司匹林包封在微球体内，在由AC磁场引起的压缩-延伸振荡下，微球的药物释放得以增强。可以通过改变所施加磁场的频率和大小以及磁场的时间曲线来控制这种主动的药物释放泵送模式。进行阿司匹林累积释放的紫外线吸收测量，以确定这些因素的影响。发现药物释放行为显着不同，这取决于所施加的电场是呈正弦变化还是以阶梯函数方式随时间变化。

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