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Biomimetic Hydroxyapatite Crystallization in Gelatin Nanoparticles Synthesized Using a Miniemulsion Process

机译:使用微乳液工艺合成的明胶纳米颗粒中的仿生羟基磷灰石结晶。

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摘要

Here, we report a novel biomimetic strategy to synthesize hydroxyapatite (HAP) inside of crosslinked gelatin nanoparticles, which serve as a nanoen vironment for crystal growth in the aqueous phase. The synthesis of gelatin nanoparticles with the inverse miniemulsion technique is very intriguing because of the flexibility offered by the technique in tailoring the properties of the gelatin nanoparticles. It can be shown that the nanoenvironment promotes a different growth environment for the crystal because of the confinement inside the particle. The formation of HAP inside the particles follows Ostwald's rule of stages. At first an amorphous phase is formed, which itself has a great potential to be used as a resorbable bone substitute. This further transforms into single crystalline HAP via an octacalcium phosphate intermediate. The solution-mediated transformation into the HAP phase without any calcination step is studied in detail using transmission electron microscopy (TEM) and X-ray diffraction (XRD) measurements.
机译:在这里,我们报告了一种新型的仿生策略,可以在交联的明胶纳米颗粒内部合成羟基磷灰石(HAP),这可作为纳米晶在水相中的生长。用逆微乳液技术合成明胶纳米颗粒非常有趣,因为该技术在调整明胶纳米颗粒性能方面具有灵活性。可以证明,由于颗粒内部的限制,纳米环境促进了晶体的不同生长环境。颗粒内部HAP的形成遵循Ostwald的阶段规则。首先,形成无定形相,其本身具有很大的潜力,可以用作可吸收的骨替代物。这进一步通过磷酸八钙中间体转化为单晶HAP。使用透射电子显微镜(TEM)和X射线衍射(XRD)测量,详细研究了无需任何煅烧步骤即可将溶液介导的转变为HAP相的过程。

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