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首页> 外文期刊>Advanced Functional Materials >'Mechanical Engineering' of Elastomeric Proteins: Toward Designing New Protein Building Blocks for Biomaterials
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'Mechanical Engineering' of Elastomeric Proteins: Toward Designing New Protein Building Blocks for Biomaterials

机译：弹性蛋白的“机械工程”：为生物材料设计新的蛋白质构件

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摘要

Elastomeric proteins are subject to stretching force under biological settings and play important roles in regulating the mechanical properties of a wide range of biological machinery. Elastomeric proteins also underlie the superb mechanical properties of many protein-based biomaterials. The developments of single molecule force spectroscopy have enabled the direct characterization of the mechanical properties of elastomeric proteins at the single molecule level and led to the new burgeoning field of research: single protein mechanics and engineering. Combined single molecule atomic force microscopy and protein engineering efforts are well under way to understand molecular determinants for the mechanical stability of elastomeric proteins and to develop methodologies to tune the mechanical properties of proteins in a rational and systematic fashion, which will lead to the 'mechanical engineering' of elastomeric proteins. Here the current status of these experimental efforts is discussed and the successes and challenges in constructing novel proteins with tailored nanomechanical proteins are highlghted. The prospect of employing such engineered artificial elastomeric proteins as building blocks for the construction of biomaterials for applications ranging from material sciences to biomedical engineering is also discussed.
机译：弹性蛋白在生物环境下会受到拉伸力的作用，并在调节多种生物机械的机械性能中发挥重要作用。弹性蛋白也是许多基于蛋白质的生物材料卓越的机械性能的基础。单分子力谱的发展使得能够在单分子水平上直接表征弹性蛋白的机械性能，并导致了新兴的研究领域：单蛋白力学和工程学。结合单分子原子力显微镜和蛋白质工程的努力正在深入研究，以了解弹性体蛋白质机械稳定性的分子决定因素，并开发一种以合理和系统的方式调节蛋白质机械性质的方法，这将导致“机械性”弹性蛋白的工程化”。这里讨论了这些实验工作的当前状态，并着重介绍了使用定制的纳米机械蛋白构建新型蛋白的成功与挑战。还讨论了使用这种工程化的人造弹性体蛋白质作为构建生物材料的基础材料的前景，该生物材料的应用范围从材料科学到生物医学工程。

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