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首页> 外文期刊>Advanced Functional Materials >Simple Route to Hydrophilic Microfluidic Chip Fabrication Using an Ultraviolet (UV)-Cured Polymer
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Simple Route to Hydrophilic Microfluidic Chip Fabrication Using an Ultraviolet (UV)-Cured Polymer

机译：使用紫外线（UV）固化的聚合物进行亲水性微流体芯片制造的简单方法

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Herein, we introduce a simple route to fabricating hydrophilic microfluidic chips with an alternative material, a UV-cured poly-urethane-related polymer, known as Norland Optical Adhesive (NOA 63). Conventionally, polydimethylsiloxane (PDMS) is widely used to fabricate microfluidic chips as an alternative to glass or SiO_2 because PDMS is easily molded and relatively cheap. However, despite these advantages, the hydrophobicity of PDMS entails critical problems when it is used in microfluidic chips because microchannels inside the microfluidic chips, which have extremely low surface tension, are difficult to fill with aqueous solution without an extra pumping system. To overcome these problems, significant efforts have been focused on developing procedures to change the PDMS surface to be hydrophilic. However, the resulting hydrophilicity is generally shortlived and the modification procedures require cumbersome multi-steps. In the present study, we demonstrate that microchan-nel-molding and microfluidic chip construction are easier using NOA 63 than when using PDMS and that the hydrophilicity of the NOA surface, which is induced by treatment with O_2 plasma, lasts longer, for at least one month. Due to the longer lasting hydrophilicity, microchannels in NOA 63 microfluidic chips are spontaneously filled with solution by capillary reaction without any extra pumping over the period. The feasibility of NOA 63-based microfabrication is verified by demonstrating NOA 63 microfluidic platforms with antibody-immobilized beads for immunoassays.
机译：在此，我们介绍了一种简单的方法来制造亲水性微流控芯片，该方法是使用另一种材料，即被称为Norland Optical Adhesive（NOA 63）的UV固化的聚氨酯相关聚合物。常规地，聚二甲基硅氧烷（PDMS）被广泛地用于制造微流体芯片以替代玻璃或SiO 2，因为PDMS易于模制并且相对便宜。然而，尽管具有这些优点，但是当PDMS用于微流控芯片中时，其疏水性仍存在关键问题，因为具有微弱的表面张力的微流控芯片内部的微通道难以在没有额外泵送系统的情况下填充水溶液。为了克服这些问题，已经集中精力开发将PDMS表面改变为亲水性的方法。然而，所得的亲水性通常是短命的，并且改性过程需要繁琐的多步骤。在本研究中，我们证明使用NOA 63比使用PDMS更容易进行微通道成型和微流控芯片构造，并且至少用O_2等离子体处理所引起的NOA表面的亲水性至少持续更长的时间。一个月。由于更长的持久亲水性，NOA 63微流控芯片中的微通道通过毛细管反应自发地充满了溶液，在此期间没有任何额外的泵送。通过展示具有抗体固定珠的NOA 63微流体平台用于免疫测定，可以验证基于NOA 63的微加工的可行性。

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