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Poly(vinyl alcohol) Scaffolds with Tailored Morphologies for Drug Delivery and Controlled Release

机译：形态独特的聚乙烯醇支架，用于药物输送和控释

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Poly(vinyl alcohol) (PVA) scaffolds are prepared by a cryogenic process that consists of the unidirectional freezing of a PVA solution. The scaffolds exhibit a microchanneled structure, the morphology of which (in terms of pore diameter, surface area, and thickness of matter accumulated between adjacent microchannels) can be finely tailored by the averaged molecular weight of PVA, the PVA concentration in the solution, and the freezing rate of the PVA solution. The resulting PVA scaffolds are suitable substrates for drug-delivery purposes, the drug release being controlled (from tens of minutes up to several days) by the morphology of the microchanneled structure. In vitro experiments reveal the efficiency of PVA scaffolds for controlling the release of ciprofloxacin into a bacteria culture medium.
机译：聚乙烯醇（PVA）支架是通过低温过程制备的，该过程包括单向冻结PVA溶液。支架具有微通道结构，其形态（就孔径，表面积和相邻微通道之间积聚的物质的厚度而言）可以通过PVA的平均分子量，溶液中PVA的浓度和PVA溶液的冷冻速度。所得的PVA支架是用于药物递送目的的合适底物，通过微通道结构的形态来控制药物的释放（从数十分钟到几天）。体外实验表明，PVA支架可有效控制环丙沙星释放到细菌培养基中。

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