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Electrophoretic separation of nanoparticles with a discrete number of functional groups

机译:电泳分离具有离散数量官能团的纳米粒子

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摘要

A concept is describe that facilitates the modification of colloidal nanoparticles of different materials with an exactly known number of variable functional groups. In particular, a procedure for the surface functionalization of nanoparticles with a controlled number of mono- or bifunctional poly(ethylene glycol) (PEG) molecules of suitable chain length is reported. Conjugates of nanoparticles with one, two, and three PEG molecules per nanoparticle could be separated using gel electrophoresis. Molecules with additional functionalities could be conjugated to the free ends of the bifunctional PEG molecules. In this way the PEG molecules act as convenient spacers that allow for the sorting of nanoparticles with a discrete number of functional groups.
机译:描述了一个概念,该概念有助于用确切已知数量的可变官能团修饰不同材料的胶体纳米颗粒。特别地,报道了具有受控链数的单或双官能聚(乙二醇)(PEG)分子的受控数量的纳米颗粒的表面官能化的方法。可以使用凝胶电泳分离每个纳米颗粒具有一个,两个和三个PEG分子的纳米颗粒的共轭物。具有附加功能的分子可以与双功能PEG分子的自由端结合。以此方式,PEG分子充当方便的间隔基,允许对具有离散数量的官能团的纳米粒子进行分选。

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