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Short-time timing of the biological activity of functionalized polyelectrolyte multilayers

机译：功能化聚电解质多层膜的生物活性的短时间计时

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摘要

This article demonstrates the tuning of the biological activity of a surface functionalized by a polyelectrolyte multilayer. The interaction of protein A with macrophages is used as the model system. The film consists of two polypeptides, poly(lysine) and poly(glutamic acid); each "build-up" solution is a mixture of the respective D- and L-enantiomers, (d and I enantiomers). Cells are deposited on top of the film, and they produce tumor necrosis factor alpha (TNF-alpha) as they come into contact with the protein. Depending upon the d/l-enantiomer ratio of the polyelectrolyte solutions used for the film build-up, and the embedding depth of the protein, the production of TNF-alpha commences after a varying induction time and displays a transition from no-production to full-production, which takes place over a period of time that depends on the film's composition and embedding depth. Thus, it is shown that by changing these two parameters the timing of the protein's activity can be accurately tuned.
机译：这篇文章演示了由聚电解质多层功能化的表面的生物活性的调整。蛋白A与巨噬细胞的相互作用用作模型系统。该膜由两种多肽组成：聚赖氨酸和聚谷氨酸。每个“堆积”溶液是各自的D和L对映体（d和I对映体）的混合物。细胞沉积在膜的顶部，当它们与蛋白质接触时会产生肿瘤坏死因子α（TNF-α）。取决于用于成膜的聚电解质溶液的d / l对映体比率和蛋白质的包埋深度，TNF-α的生产在变化的诱导时间后开始，并显示从无生产到无生产的过渡。整个制作过程需要一段时间，具体取决于胶片的成分和包埋深度。因此，表明通过改变这两个参数，可以精确地调节蛋白质活性的时间。

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