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Al_xGa_(1-x)N-A New Material System for Biosensors

机译：Al_xGa_（1-x）N-A生物传感器新材料系统

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摘要

The applicability of the group III nitride material system for the fabrication of semiconductor-based biosensors is demonstrated. The operation of ion-sensitive field-effect transistors (ISFETs) based o AlGaN/GaN heterostructures in aqueous electrolytes is shown to be characterized by high sensitivity and low drift. FIbroblasts in contact with oxidized and as-deposited AlGaN surfaces are demonstrated to survive at least for 24 h, indicating that these surfaces are chemically robust and non-toxic against living cells. Surface hydrophilization using thermal oxidation allows the deposition of highly mobile lipid membranes by vesicle fusion. The homogeneity and the diffusion properties of phospholipids with different net charges were analyzed by fluorescence microscopy and constant photobleaching, taking advantage of the optical transparency of the AlGaN material system. The obtained results reveal that AlGaN-based devices are promising candidates for future multifunctional biosensors.
机译：证明了III族氮化物材料系统在基于半导体的生物传感器的制造中的适用性。在水性电解质中基于AlGaN / GaN异质结构的离子敏感场效应晶体管（ISFET）的运行具有高灵敏度和低漂移的特点。已证明与氧化的和沉积的AlGaN表面接触的成纤维细胞可以存活至少24小时，这表明这些表面在化学上坚固并且对活细胞无毒。使用热氧化的表面亲水化允许通过囊泡融合沉积高度可移动的脂质膜。利用AlGaN材料系统的光学透明性，通过荧光显微镜和恒定光漂白对具有不同净电荷的磷脂的均匀性和扩散特性进行了分析。获得的结果表明，基于AlGaN的器件是未来多功能生物传感器的有希望的候选者。

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