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Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases

机译：用于治疗脑血管疾病的血管内金属器械

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摘要

Cerebrovascular disease involves various medical disorders that obstruct brain blood vessels or deteriorate cerebral circulation, resulting in ischemic or hemorrhagic stroke. Nowadays, platinum coils with or without biological modification have become routine embolization devices to reduce the risk of cerebral aneurysm bleeding. Additionally, many intracranial stents, flow diverters, and stent retrievers have been invented with uniquely designed structures. To accelerate the translation of these devices into clinical usage, an in-depth understanding of the mechanical and material performance of these metal-based devices is critical. However, considering the more distal location and tortuous anatomic characteristics of cerebral arteries, present devices still risk failing to arrive at target lesions. Consequently, more flexible endovascular devices and novel designs are under urgent demand to overcome the deficiencies of existing devices. Herein, the pros and cons of the current structural designs are discussed when these devices are applied to the treatment of diseases ranging broadly from hemorrhages to ischemic strokes, in order to encourage further development of such kind of devices and investigation of their use in the clinic. Moreover, novel biodegradable materials and drug elution techniques, and the design, safety, and efficacy of personalized devices for further clinical applications in cerebral vasculature are discussed.
机译：脑血管疾病涉及各种阻塞脑血管或恶化脑循环的医学疾病，导致缺血性或出血性中风。如今，经过或不经过生物修饰的铂金线圈已成为常规的栓塞设备，以减少脑动脉瘤出血的风险。另外，已经发明了具有独特设计的结构的许多颅内支架，分流器和支架取回器。为了加快将这些设备转换为临床用途，深入了解这些基于金属的设备的机械和材料性能至关重要。然而，考虑到脑动脉的更远端位置和弯曲的解剖特征，目前的装置仍然有无法到达目标病变的风险。因此，迫切需要更灵活的血管内装置和新颖的设计来克服现有装置的不足。在本文中，讨论了当将这些设备应用于从出血到缺血性中风等广泛疾病的治疗时，当前结构设计的利弊，以鼓励此类设备的进一步开发和在临床上的研究用途。 。此外，还讨论了新颖的可生物降解材料和药物洗脱技术，以及用于脑血管系统进一步临床应用的个性化设备的设计，安全性和功效。

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  • 来源
    《Advanced Materials》 |2019年第8期|1805452.1-1805452.44|共44页
  • 作者

    Zhu Yueqi; Zhang Hongbo; Zhang Yiran; Wu Huayin; Wei Liming; Zhou Gen; Zhang Yuezhou; Deng Lianfu; Cheng Yingsheng; Li Minghua; Santos Helder A.; Cui Wenguo;

  • 作者单位

    Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Radiol, 600 Yishan Rd, Shanghai 200233, Peoples R China;

    Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Key Lab Prevent & Treatment Bone & Joint, Shanghai Inst Traumatol & Orthopaed,Sch Med, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China|Abo Akad Univ, Dept Pharmaceut Sci Lab, FI-20520 Turku, Finland|Univ Turku, Turku Ctr Biotechnol, FI-20520 Turku, Finland|Abo Akad Univ, FI-20520 Turku, Finland;

    Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Radiol, 600 Yishan Rd, Shanghai 200233, Peoples R China|Abo Akad Univ, Dept Pharmaceut Sci Lab, FI-20520 Turku, Finland|Univ Turku, Turku Ctr Biotechnol, FI-20520 Turku, Finland|Abo Akad Univ, FI-20520 Turku, Finland;

    Harvard Univ, Harvard John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 USA;

    Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Radiol, 600 Yishan Rd, Shanghai 200233, Peoples R China;

    Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Radiol, 600 Yishan Rd, Shanghai 200233, Peoples R China;

    Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Key Lab Prevent & Treatment Bone & Joint, Shanghai Inst Traumatol & Orthopaed,Sch Med, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China;

    Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Radiol, 600 Yishan Rd, Shanghai 200233, Peoples R China;

    Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Radiol, 600 Yishan Rd, Shanghai 200233, Peoples R China;

    Univ Helsinki, Fac Pharm, Drug Res Program, Div Pharmaceut Chem & Technol, FI-00014 Helsinki, Finland|Univ Helsinki, Helsinki Inst Life Sci, FI-00014 Helsinki, Finland;

    Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Key Lab Prevent & Treatment Bone & Joint, Shanghai Inst Traumatol & Orthopaed,Sch Med, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    biodegradable; cerebrovascular disease; drug elution; flexible endovascular devices; metal-based stents;

    机译：可生物降解;脑血管疾病;药物洗脱;柔性血管内装置;金属基支架;

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