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首页> 外文期刊>Advanced Materials >X-ray-Controlled Bilayer Permeability of Bionic Nanocapsules Stabilized by Nucleobase Pairing Interactions for Pulsatile Drug Delivery
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X-ray-Controlled Bilayer Permeability of Bionic Nanocapsules Stabilized by Nucleobase Pairing Interactions for Pulsatile Drug Delivery

机译：X射线控制的通过核碱基配对相互作用稳定的仿生纳米胶囊的双层渗透性，用于脉冲药物递送。

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摘要

The targeted and sustained drug release from stimuli-responsive nanodelivery systems is limited by the irreversible and uncontrolled disruption of the currently used nanostructures. Bionic nanocapsules are designed by cross-linking polythymine and photoisomerized polyazobenzene (PETAzo) with adenine-modified ZnS (ZnS-A) nanoparticles (NPs) via nucleobase pairing. The ZnS-A NPs convert X-rays into UV radiation that isomerizes the azobenzene groups, which allows controlled diffusion of the active payloads across the bilayer membranes. In addition, the nucleobase pairing interactions between PETAzo and ZnS-A prevent drug leakage during their in vivo circulation, which not only enhances tumor accumulation but also maintains stability. These nanocapsules with tunable permeability show prolonged retention, remotely controlled drug release, enhanced targeted accumulation, and effective antitumor effects, indicating their potential as an anticancer drug delivery system.
机译：从刺激响应性纳米递送系统中靶向和持续释放药物受到当前使用的纳米结构不可逆转和不受控制的破坏的限制。仿生纳米胶囊是通过核苷碱基配对将多胸腺嘧啶和光异构化的聚偶氮苯（PETAzo）与腺嘌呤修饰的ZnS（ZnS-A）纳米颗粒（NPs）交联而设计的。 ZnS-A NP将X射线转换为紫外线辐射，使偶氮苯基团异构化，从而使活性有效载荷在双层膜上的扩散受到控制。此外，PETAzo和ZnS-A之间的核碱基配对相互作用可防止药物在其体内循环过程中泄漏，这不仅增强了肿瘤的积累，而且还保持了稳定性。这些具有可调渗透性的纳米胶囊显示出延长的保留时间，远程控制的药物释放，增强的靶向积累和有效的抗肿瘤作用，表明它们具有作为抗癌药物递送系统的潜力。

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