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首页> 外文期刊>Advanced Materials >Glucose-Responsive Composite Microneedle Patch for Hypoglycemia-Triggered Delivery of Native Glucagon
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Glucose-Responsive Composite Microneedle Patch for Hypoglycemia-Triggered Delivery of Native Glucagon

机译：低血糖触发的天然胰高血糖素递送的葡萄糖反应性复合微针贴剂。

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Insulin-dependent patients with diabetes mellitus require multiple daily injections of exogenous insulin to combat hyperglycemia. However, administration of excess insulin can lead to hypoglycemia, a life-threatening condition characterized by abnormally low blood glucose levels (BGLs). To prevent hypoglycemia associated with intensive insulin therapy, a "smart" composite microneedle (cMN) patch is developed, which releases native glucagon at low glucose levels. The cMN patch is composed of a photo-crosslinked methacrylated hyaluronic acid (MeHA) microneedle array with embedded multifunctional microgels. The microgels incorporate zwitterionic moieties that stabilize loaded glucagon and phenylboronic acid moieties that provide glucose-dependent volume change to facilitate glucagon release. Hypoglycemia-triggered release of structurally unchanged glucagon from the cMN patch is demonstrated in vitro and in a rat model of type 1 diabetes (T1D). Transdermal application of the patch prevented insulin-induced hypoglycemia in the diabetic rats. This work is the first demonstration of a glucose-responsive glucagon-delivery MN patch for the prevention of hypoglycemia, which has a tremendous potential to reduce the dangers of intensive insulin therapy and improve the quality of life of patients with diabetes and their caregivers.
机译：胰岛素依赖型糖尿病患者需要每天多次注射外源性胰岛素来对抗高血糖症。但是，过量胰岛素的使用会导致低血糖，这是一种以异常低血糖水平（BGL）为特征的危及生命的疾病。为了防止与强化胰岛素治疗相关的低血糖症，开发了一种“智能”复合微针（cMN）贴剂，该贴剂可在低葡萄糖水平下释放天然胰高血糖素。 cMN贴片由具有嵌入式多功能微凝胶的光交联的甲基丙烯酸透明质酸（MeHA）微针阵列组成。所述微凝胶掺入了两性离子部分，该两性离子部分稳定了负载的胰高血糖素，而苯基硼酸部分提供了葡萄糖依赖性的体积变化，从而促进了胰高血糖素的释放。低血糖触发的cMN贴片中结构不变的胰高血糖素的释放在体外和1型糖尿病（T1D）大鼠模型中得到证实。贴剂的透皮施用防止了糖尿病大鼠中胰岛素诱导的低血糖。这项工作是用于预防低血糖症的葡萄糖反应性胰高血糖素递送MN贴片的首次展示，该贴片具有巨大的潜力，可以减少强化胰岛素治疗的危险并改善糖尿病患者及其护理人员的生活质量。

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