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首页> 外文期刊>Advanced Materials >Looking into the Future: Toward Advanced 3D Biomaterials for Stem-Cell-Based Regenerative Medicine
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Looking into the Future: Toward Advanced 3D Biomaterials for Stem-Cell-Based Regenerative Medicine

机译：展望未来：面向干细胞再生医学的先进3D生物材料

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摘要

Stem-cell-based therapies have the potential to provide novel solutions for the treatment of a variety of diseases, but the main obstacles to such therapies lie in the uncontrolled differentiation and functional engraftment of implanted tissues. The physicochemical microenvironment controls the self-renewal and differentiation of stem cells, and the key step in mimicking the stem cell microenvironment is to construct a more physiologically relevant 3D culture system. Material-based 3D assemblies of stem cells facilitate the cellular interactions that promote morphogenesis and tissue organization in a similar manner to that which occurs during embryogenesis. Both natural and artificial materials can be used to create 3D scaffolds, and synthetic organic and inorganic porous materials are the two main kinds of artificial materials. Nanotechnology provides new opportunities to design novel advanced materials with special physicochemical properties for 3D stem cell culture and transplantation. Herein, the advances and advantages of 3D scaffold materials, especially with respect to stem-cell-based therapies, are first outlined. Second, the stem cell biology in 3D scaffold materials is reviewed. Third, the progress and basic principles of developing 3D scaffold materials for clinical applications in tissue engineering and regenerative medicine are reviewed.
机译：基于干细胞的疗法有潜力为多种疾病的治疗提供新颖的解决方案，但此类疗法的主要障碍在于植入组织的不受控制的分化和功能性植入。物理化学微环境控制着干细胞的自我更新和分化，模拟干细胞微环境的关键步骤是构建更具生理相关性的3D培养系统。基于材料的干细胞3D装配体以类似于胚胎发生过程中的方式，促进了促进形态发生和组织组织的细胞相互作用。天然材料和人造材料均可用于创建3D支架，合成的有机和无机多孔材料是两种主要的人造材料。纳米技术为3D干细胞培养和移植设计具有特殊物理化学性质的新型先进材料提供了新的机会。在此，首先概述了3D支架材料的进步和优势，尤其是在基于干细胞的疗法方面。其次，综述了3D支架材料中的干细胞生物学。第三，回顾了开发用于组织工程和再生医学的3D支架材料的进展和基本原理。

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  • 来源
    《Advanced Materials》 |2018年第17期|1705388.1-1705388.20|共20页
  • 作者

    Liu Zhongmin; Tang Mingliang; Zhao Jinping; Chai Renjie; Kang Jiuhong;

  • 作者单位

    Tongji Univ, Sch Med, Shanghai East Hosp, Dept Cardiovasc & Thorac Surg,Translat Med Ctr St, Shanghai 200120, Peoples R China;

    Southeast Univ, Inst Life Sci, Minist Educ, Key Lab Dev Genes & Human Dis, Nanjing 210096, Jiangsu, Peoples R China;

    Tongji Univ, Clin & Translat Res Ctr, Shanghai Matern & Infant Hlth Hosp 1,Sch Life Sci, Shanghai Key Lab Signaling & Dis Res,Collaborat I, 1239 Siping Rd, Shanghai 200092, Peoples R China;

    Southeast Univ, Inst Life Sci, Minist Educ, Key Lab Dev Genes & Human Dis, Nanjing 210096, Jiangsu, Peoples R China;

    Tongji Univ, Clin & Translat Res Ctr, Shanghai Matern & Infant Hlth Hosp 1,Sch Life Sci, Shanghai Key Lab Signaling & Dis Res,Collaborat I, 1239 Siping Rd, Shanghai 200092, Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    3D biomaterials; regenerative medicine; stem cells; tissue engineering; artificial organs;

    机译：3D生物材料;再生医学;干细胞;组织工程;人工器官;

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