Intelligent Albumin-MnO2 Nanoparticles as pH-/H2O2-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy

Chen Qian; Feng Liangzhu; Liu Jingjing; Zhu Wenwen; Dong Ziliang; Wu Yifan; Liu Zhuang

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Intelligent Albumin-MnO2 Nanoparticles as pH-/H2O2-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy

机译：智能白蛋白-MnO2纳米粒子作为pH- / H2O2响应型可分离纳米载体，可调节肿瘤缺氧有效联合治疗。

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A unique type of pH/H2O2 dual-responsive intelligent nanoscale delivery system based on albumin-coated MnO2 is presented, which is capable of modulating the tumor microenvironment (TME) by relieving hypoxia. Additionally, TME-responsive size changes enable effective intratumor diffusion. A highly effective combined photodynamic and chemotherapy is realized with these nanoparticles in a mouse tumor model.

机译：提出了一种独特的基于白蛋白包被的MnO2的pH / H2O2双响应智能纳米级传递系统，该系统能够通过缓解缺氧来调节肿瘤微环境（TME）。另外，TME响应的大小变化可实现有效的肿瘤内扩散。这些纳米颗粒在小鼠肿瘤模型中实现了高效的光动力学和化学疗法的结合。

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来源
《Advanced Materials》 |2016年第33期|7129-7136|共8页
作者
Chen Qian; Feng Liangzhu; Liu Jingjing; Zhu Wenwen; Dong Ziliang; Wu Yifan; Liu Zhuang;
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Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China;

Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China;

Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China;

Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China;

Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China;

Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China;

Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China;

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1. Albumin-MnO2 gated hollow mesoporous silica nanosystem for modulating tumor hypoxia and synergetic therapy of cervical carcinoma [J] . Fang Junfeng, Wang Qiu, Yang Guangji, Colloids and Surfaces, B. Biointerfaces . 2019,第期

机译：白蛋白-MNO2门控中空介孔二氧化硅纳米系统调节肿瘤缺氧及宫颈癌的协同治疗
2. Intelligent MnO2 Nanosheets Anchored with Upconversion Nanoprobes for Concurrent pH-/H2O2-Responsive UCL Imaging and Oxygen-Elevated Synergetic Therapy [J] . Fan Wenpei, Bu Wenbo, Shen Bo, Advanced Materials . 2015,第28期

机译：上转换纳米探针锚定的智能MnO2纳米片，用于同时进行pH- / H2O2响应的UCL成像和增氧协同治疗
3. Oxygen-Based Nanocarriers to Modulate Tumor Hypoxia for Ameliorated Anti-Tumor Therapy: Fabrications, Properties, and Future Directions [J] . Li Xianqiang, Wu Yue, Zhang Rui, Frontiers in Molecular Biosciences . 2021,第a期

机译：基于氧的纳米载体调节肿瘤缺氧进行改善的抗肿瘤疗法：制造，性质和未来方向
4. NIR Triggered Photodynamic/Chemotherapy in Combination with Immunotherapy by Using Cascade Upconversion Nanoparticles for Elimination of Primary Tumor and Remission of Metastasis [C] . Jun Chen Society for Biomaterials annual meeting and exposition . 2018

机译：NIR触发光动力学/化学疗法与免疫疗法相结合，使用级联上转换纳米粒子消除原发性肿瘤和转移的缓解
5. Tumor hypoxia, the Warburg effect, and multidrug resistance: Modulation of hypoxia induced MDR using EGFR-targeted polymer blend nanocarriers for combination paclitaxel/lonidamine therapy. [D] . Jabr-Milane, Lara Scheherazade. 2010

机译：肿瘤缺氧，Warburg效应和多药耐药性：使用紫杉醇/ LONIDamine疗法联合使用EGFR靶向的聚合物共混纳米载体，调节缺氧诱导的MDR。
6. Oxygen-Based Nanocarriers to Modulate Tumor Hypoxia for Ameliorated Anti-Tumor Therapy: Fabrications Properties and Future Directions [O] . Xianqiang Li, Yue Wu, Rui Zhang, 2021

机译：基于氧的纳米载体调节肿瘤缺氧进行改善的抗肿瘤疗法：制造性质和未来方向
7. Synthesis of a core/satellite-like multifunctional nanocarrier for pH- and NIR-triggered intracellular chemothermal therapy and tumor imaging [O] . Xue Yang, Jun Xiong, Pengchao Qiu, 2017

机译：合成pH-和NIR-触发的细胞内化学热疗法和肿瘤成像的核心/卫星样多功能纳米载体

Intelligent Albumin-MnO2 Nanoparticles as pH-/H2O2-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy

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