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3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs

机译：血管化，异源性细胞组织构建体的3D生物打印

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摘要

The ability to create 3D vascularized tissues on demand would enable scientific and technological advances in tissue engineering, drug screening, and organ repair. To produce 3D engineered tissue constructs that mimic natural tissues and, ultimately, organs, several key components - cells, extracellular matrix (ECM), and vasculature - need to be patterned in precise geometries. Each of these components plays a vital role in imparting, supporting, or sustaining the biomimetic function of the engineered tissue construct, respectively. Perhaps the most important of these components is the vasculature; without proximity to a perfused microvasculature that provides efficient nutrient, growth/signaling factor, and waste transport, most cells within bulk tissue constructs will not remain viable. In fact, 3D engineered tissue constructs quickly develop necrotic regions without perfusable vasculature within a few hundred microns of each cell. Unfortunately, the inability to create vascular networks within engineered tissue constructs has hindered progress in the field of tissue engineering for decades.
机译：按需创建3D血管化组织的能力将使组织工程，药物筛选和器官修复方面的科学技术进步。为了生产能够模仿天然组织以及最终模仿器官的3D工程组织构造，需要在精确的几何图形中构图几个关键组件-细胞，细胞外基质（ECM）和脉管系统。这些组分中的每一个分别在赋予，支持或维持工程组织构造的仿生功能中起着至关重要的作用。这些成分中最重要的也许是脉管系统。如果不靠近提供有效营养，生长/信号传导因子和废物运输的灌注微血管，散装组织构建物中的大多数细胞将无法保持活力。实际上，经过3D工程处理的组织构建体会在每个细胞几百微米内迅速形成坏死区域，而没有可灌注的脉管系统。不幸的是，数十年来，无法在工程组织构造中创建血管网络阻碍了组织工程领域的进展。

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  • 来源
    《Advanced Materials》 |2014年第19期|3124-3130|共7页
  • 作者

    David B. Kolesky; Ryan L. Truby; A. Sydney Gladman; Travis A. Busbee; Kimberly A. Homan; Jennifer A. Lewis;

  • 作者单位

    School of Engineering and Applied Sciences Wyss Institute for Biologically Inspired Engineering Harvard University Cambridge, MA 02138, USA;

    School of Engineering and Applied Sciences Wyss Institute for Biologically Inspired Engineering Harvard University Cambridge, MA 02138, USA;

    School of Engineering and Applied Sciences Wyss Institute for Biologically Inspired Engineering Harvard University Cambridge, MA 02138, USA;

    School of Engineering and Applied Sciences Wyss Institute for Biologically Inspired Engineering Harvard University Cambridge, MA 02138, USA;

    School of Engineering and Applied Sciences Wyss Institute for Biologically Inspired Engineering Harvard University Cambridge, MA 02138, USA;

    School of Engineering and Applied Sciences Wyss Institute for Biologically Inspired Engineering Harvard University Cambridge, MA 02138, USA;

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