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Thermoforming of Film-Based Biomedical Microdevices

机译：薄膜生物医学微器件的热成型

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摘要

For roughly ten years now, a new class of polymer micromoulding processes comes more and more into the focus both of the microtechnology and the biomedical engineering community. These processes can be subsumed under the term "microthermoforming". In microthermoforming, thin polymer films are heated to a softened, but still solid state and formed to thin-walled microdevices by three-dimensional stretching. The high material coherence during forming is in contrast to common polymer microreplication processes where the material is processed in a liquid or flowing state. It enables the preservation of premodi-fications of the film material. In this progress report, we review the still young state of the art of microthermoforming technology as well as its first applications. So far, the applications are mainly in the biomedical field. They benefit from the fact that thermoformed microdevices have unique properties resulting from their special, unusual morphology. The focus of this paper is on the impact of the new class of micromoulding processes and the processed film materials on the characteristics of the moulded microdevices and on their applications.
机译：在大约十年的时间里，一类新型的聚合物微模塑工艺越来越受到微技术和生物医学工程界的关注。这些过程可以包含在术语“微热成型”下。在微热成型中，将聚合物薄膜加热至软化但仍为固态，并通过三维拉伸将其形成为薄壁微器件。与在材料以液态或流动态进行加工的普通聚合物微复制工艺相反，成型过程中的高材料凝聚力。它能够保持薄膜材料的预改性。在此进度报告中，我们回顾了微热成型技术的最新技术及其首次应用。到目前为止，应用主要在生物医学领域。他们受益于以下事实：热成型的微型设备具有特殊的，不寻常的形态，从而具有独特的性能。本文的重点是新型微模塑工艺和加工过的薄膜材料对模塑微器件特性及其应用的影响。

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  • 来源
    《Advanced Materials》 |2011年第11期|p.1311-1329|共19页
  • 作者

    Roman Truckenmuller; Stefan Giselbrecht; Nicolas Rivron; Eric Gottwald; Volker Saile; Albert van den Berg; Matthias Wessling; Clemens van Blitterswijk;

  • 作者单位

    Department of Tissue Regeneration MIRA Institute for Biomedical Technology and Technical Medicine University of Twente 7522 NB Enschede, The Netherlands;

    Institute for Biological Interfaces Karlsruhe Institute of Technology 76344 Eggenstein-Leopoldshafen, Germany;

    Department of Tissue Regeneration MIRA Institute for Biomedical Technology and Technical Medicine University of Twente 7522 NB Enschede, The Netherlands;

    Institute for Biological Interfaces Karlsruhe Institute of Technology 76344 Eggenstein-Leopoldshafen, Germany;

    Institute for Microstructure Technology Karlsruhe Institute of Technology 76131 Karlsruhe, Germany;

    BIOS, The Lab-on-a-Chip Group MESA+ Institute for Nanotechnology University of Twente 522 NM Enschede, The Netherlands;

    Membrane Science and Technology MIRA Institute for Biomedical Technology and Technical Medicine University of Twente 7522 NB Enschede, The Netherlands;

    Department of Tissue Regeneration MIRA Institute for Biomedical Technology and Technical Medicine University of Twente 7522 NB Enschede, The Netherlands;

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