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首页> 外文期刊>Advanced Materials >Chiral Cu_xOS@ZIF-8 Nanostructures for Ultrasensitive Quantification of Hydrogen Sulfide In Vivo
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Chiral Cu_xOS@ZIF-8 Nanostructures for Ultrasensitive Quantification of Hydrogen Sulfide In Vivo

机译：手性Cu_xos @ ZIF-8用于超细硫化氢的超敏化定量体内硫化物的纳米结构

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摘要

In this study, a CuxOS@ZIF-8 nanostructure is fabricated to quantify the levels of hydrogen sulfide (H2S) in living cells and in vivo. Zeolitic lmidazolate framework-8 (ZIF-8) is chosen as an encapsulation shell to improve the selectivity of this probe. Using this unique nanostructure, ultrasensitive quantification and bioimaging of H2S in living cells are successfully achieved. The lower limit of detection is 0.8 and 5.3 nmol per 10(6) cells for circular dichroism and fluorescence modes, respectively. It is found that the chiral CuxOS NPs transformed into achiral CuxS NPs contribute to the ultrasensitive detection. Notably, this probe can also be carried out to detect and track H2S levels in tumor-bearing animals. The discoveries put forward for the creation of a detection platform for quantitative tracking and analysis in clinic.
机译：在该研究中，制造了一种ZIF-8纳米结构，以量化活细胞和体内硫化氢（H2S）的水平。选择沸石Lmidazolate框架-​​8（ZIF-8）作为包封壳，以改善该探针的选择性。使用这种独特的纳米结构，成功实现了活细胞中H2S的超敏定量和生物模拟。检测的下限分别为每10（6）个细胞的0.8和5.3nmol，用于圆形二中中和荧光模式。结果发现，转化成Afhiral Cuxs NPS的手性杂环菌NP有助于超细检测。值得注意的是，该探针也可以进行以检测和跟踪肿瘤动物中的H2S水平。发现提出了在诊所的定量跟踪和分析中进行定量跟踪和分析的检测平台。

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  • 来源
    《Advanced Materials》 |2020年第19期|1906580.1-1906580.7|共7页
  • 作者

    Yuan Aimeng; Hao Changlong; Wu Xiaoling; Sun Maozhong; Qu Aihua; Xu Liguang; Kuang Hua; Xu Chuanlai;

  • 作者单位

    Jiangnan Univ Sch Food Sci & Technol State Key Lab Food Sci & Technol Int Joint Res Lab Biointerface & Biodetect Wuxi 214122 Jiangsu Peoples R China;

    Jiangnan Univ Sch Food Sci & Technol State Key Lab Food Sci & Technol Int Joint Res Lab Biointerface & Biodetect Wuxi 214122 Jiangsu Peoples R China;

    Jiangnan Univ Sch Food Sci & Technol State Key Lab Food Sci & Technol Int Joint Res Lab Biointerface & Biodetect Wuxi 214122 Jiangsu Peoples R China;

    Jiangnan Univ Sch Food Sci & Technol State Key Lab Food Sci & Technol Int Joint Res Lab Biointerface & Biodetect Wuxi 214122 Jiangsu Peoples R China;

    Jiangnan Univ Sch Food Sci & Technol State Key Lab Food Sci & Technol Int Joint Res Lab Biointerface & Biodetect Wuxi 214122 Jiangsu Peoples R China;

    Jiangnan Univ Sch Food Sci & Technol State Key Lab Food Sci & Technol Int Joint Res Lab Biointerface & Biodetect Wuxi 214122 Jiangsu Peoples R China;

    Jiangnan Univ Sch Food Sci & Technol State Key Lab Food Sci & Technol Int Joint Res Lab Biointerface & Biodetect Wuxi 214122 Jiangsu Peoples R China;

    Jiangnan Univ Sch Food Sci & Technol State Key Lab Food Sci & Technol Int Joint Res Lab Biointerface & Biodetect Wuxi 214122 Jiangsu Peoples R China;

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  • 正文语种 eng
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  • 关键词

    chiral materials; circular dichroism; CuxOS@ZIF-8; hydrogen sulfide; quantitative analysis;

    机译：手性材料;圆形二色性;葫芦@ ZIF-8;硫化氢;定量分析;

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