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首页> 外文期刊>Advanced Materials >Emerging Roles of 1D Vertical N a restructures in Orchestrating Immune Cell Functions
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Emerging Roles of 1D Vertical N a restructures in Orchestrating Immune Cell Functions

机译：1D垂直N的新兴角色在协调免疫细胞功能中的重组

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摘要

Engineered nano-bio cellular interfaces driven by 1D vertical nanostructures (1D-VNS) are set to prompt radical progress in modulating cellular processes at the nanoscale. Here, tuneable cell-VNS interfacial interactions are probed and assessed, highlighting the use of 1D-VNS in immunomodulation, and intracellular delivery into immune cells-both crucial in fundamental and translational biomedical research. With programmable topography and adaptable surface functionalization, 1D-VNS provide unique biophysical and biochemical cues to orchestrate innate and adaptive immunity, both ex vivo and in vivo. The intimate nanoscale cell-VNS interface leads to membrane penetration and cellular deformation, facilitating efficient intracellular delivery of diverse bioactive cargoes into hard-to-transfect immune cells. The unsettled interfacial mechanisms reported to be involved in VNS-mediated intracellular delivery are discussed. By identifying up-to-date progress and fundamental challenges of current 1D-VNS technology in immune-cell manipulation, it is hoped that this report gives timely insights for further advances in developing 1D-VNS as a safe, universal, and highly scalable platform for cell engineering and enrichment in advanced cancer immunotherapy such as chimeric antigen receptor-T therapy.
机译：由1D垂直纳米结构（1D-VNS）驱动的工程化的纳米生物细胞界面被设定以提示在纳米级调节细胞过程中的激进进展。在这里，探测和评估可调谐的电池VNS界面相互作用，突出显示使用1D-VNS在免疫调节中的使用，以及细胞内输送到免疫细胞中 - 在基本和翻译的生物医学研究中至关重要。通过可编程地形和适应性表面官能化，1D-VNS提供独特的生物物理和生化线索，以协调先天和适应性免疫，既外体内和体内则。亲密的纳米级电池-VNS界面导致膜穿透和细胞变形，促进了有效的细胞内递送各种生物活性货物，进入硬染色的免疫细胞。讨论了据报道涉及VNS介导的细胞内递送的未悬垂的界面机制。通过确定当前1D-VNS技术在免疫细胞操作中的最新进展和基本挑战，希望本报告及时了解开发1D-VNS作为安全，通用和高度可扩展平台的进一步进展用于细胞工程和富集晚期癌症免疫疗法，如嵌合抗原受体-T治疗。

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  • 来源
    《Advanced Materials》 |2020年第40期|2001668.1-2001668.25|共25页
  • 作者

    Chen Yaping; Wang Ji; Li Xiangling; Hu Ning; Voelcker Nicolas H.; Xie Xi; Elnathan Roey;

  • 作者单位

    Monash Univ Monash Inst Pharmaceut Sci 381 Royal Parade Parkville Vic 3052 Australia|Victorian Node Australian Natl Fabricat Facil Melbourne Ctr Nanofabricat 151 Wellington Rd Clayton Vic 3168 Australia;

    Sun Yat Sen Univ Affiliated Hosp 1 Guangzhou 510006 Peoples R China;

    Sun Yat Sen Univ Sch Elect & Informat Technol State Key Lab Optoelect Mat & Technol Guangzhou 510006 Peoples R China;

    Sun Yat Sen Univ Sch Elect & Informat Technol State Key Lab Optoelect Mat & Technol Guangzhou 510006 Peoples R China;

    Monash Univ Monash Inst Pharmaceut Sci 381 Royal Parade Parkville Vic 3052 Australia|Victorian Node Australian Natl Fabricat Facil Melbourne Ctr Nanofabricat 151 Wellington Rd Clayton Vic 3168 Australia|Monash Univ Dept Mat Sci & Engn 22 Alliance Lane Clayton Vic 3168 Australia|Commonwealth Sci & Ind Res Org CSIRO Clayton Vic 3168 Australia|INM Leibniz Inst New Mat Campus D2 2 D-66123 Saarbrucken Germany;

    Sun Yat Sen Univ Affiliated Hosp 1 Guangzhou 510006 Peoples R China|Sun Yat Sen Univ Sch Elect & Informat Technol State Key Lab Optoelect Mat & Technol Guangzhou 510006 Peoples R China;

    Monash Univ Monash Inst Pharmaceut Sci 381 Royal Parade Parkville Vic 3052 Australia|Victorian Node Australian Natl Fabricat Facil Melbourne Ctr Nanofabricat 151 Wellington Rd Clayton Vic 3168 Australia|Monash Univ Dept Mat Sci & Engn 22 Alliance Lane Clayton Vic 3168 Australia;

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  • 正文语种 eng
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  • 关键词

    1D vertical nanostructures; immune cells; immunomodulation; intracellular delivery; nano-bio interface;

    机译：1D垂直纳米结构;免疫细胞;免疫调节;细胞内递送;纳米生物界面;

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