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Remotely Triggerable Drug Delivery Systems

机译:远程可触发药物输送系统

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摘要

Triggerable drug delivery systems enable on-demand controlled release profiles that may enhance therapeutic effectiveness and reduce systemic toxicity. Recently, a number of new materials have been developed that exhibit sensitivity to visible light, near-infrared (NIR) light, ultrasound, or magnetic fields. This responsiveness can be triggered remotely to provide flexible control of dose magnitude and timing. Here we review triggerable materials that range in scale from nano to macro, and are activated by a range of stimuli.
机译:可触发的药物输送系统可实现按需控制释放,从而可增强治疗效果并降低全身毒性。最近,已经开发出许多对可见光,近红外(NIR)光,超声或磁场表现出敏感性的新材料。可以远程触发此响应,以灵活控制剂量大小和时间。在这里,我们回顾了可触发材料,其范围从纳米到宏观,并被一系列刺激激活。

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  • 来源
    《Advanced Materials》 |2010年第44期|p.4925-4943|共19页
  • 作者单位

    Laboratory for Biomaterials and Drug Delivery Department of Anesthesiology Division of Critical Care Medicine Children's Hospital Boston, Harvard Medical School 300 Longwood Avenue, Boston, MA 02115 (USA),Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology 77 Massachusetts Avenue, Cambridge, MA 02139 (USA);

    rnLaboratory for Biomaterials and Drug Delivery Department of Anesthesiology Division of Critical Care Medicine Children's Hospital Boston Harvard Medical School 300 Longwood Avenue, Boston, MA 02115 (USA),Department of Chemical Engineering Massachusetts Institute of Technology 45 Carleton Street, Cambridge, MA 02142 (USA);

    rnLaboratory for Biomaterials and Drug Delivery Department of Anesthesiology Division of Critical Care Medicine Children's Hospital Boston, Harvard Medical School 300 Longwood Avenue, Boston, MA 02115 (USA),Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology 77 Massachusetts Avenue, Cambridge, MA 02139 (USA);

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