Polymeric Materials For Gene Delivery And Dna Vaccination

David N. Nguyen; Jordan J. Creen; Juliana M. Chan; Robert Longer; Daniel G. Anderson

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Polymeric Materials For Gene Delivery And Dna Vaccination

机译：用于基因传递和Dna疫苗接种的聚合材料

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Gene delivery holds great potential for the treatment of many different diseases. Vaccination with DNA holds particular promise, and may provide a solution to many technical challenges that hinder traditional vaccine systems including rapid development and production and induction of robust cell-mediated immune responses. However, few candidate DNA vaccines have progressed past preclinical development and none have been approved for human use. This Review focuses on the recent progress and challenges facing materials design for nonviral DNA vaccine drug delivery systems. In particular, we highlight work on new polymeric materials and their effects on protective immune activation, gene delivery, and current efforts to optimize polymeric delivery systems for DNA vaccination.

机译：基因传递在治疗许多不同疾病方面具有巨大潜力。用DNA进行疫苗接种具有特殊的前景，并可能为解决许多阻碍传统疫苗系统的技术难题提供解决方案，包括快速开发和生产以及诱导强大的细胞介导的免疫反应。但是，很少有候选DNA疫苗经过临床前开发，没有一种被批准用于人类。这篇综述着重于非病毒DNA疫苗药物递送系统材料设计的最新进展和挑战。特别是，我们重点介绍了新型聚合物材料的研究及其对保护性免疫激活，基因传递的影响，以及当前为优化DNA疫苗接种的聚合物传递系统所做的努力。

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《Advanced Materials》 |2009年第8期|847-867|共21页
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David N. Nguyen; Jordan J. Creen; Juliana M. Chan; Robert Longer; Daniel G. Anderson;
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1. DNA Pharmaceuticals: Formulation and Delivery in Gene Therapy,DNA Vaccination and Immunotherapy [J] . ChemMedChem Group ChemMedChem . 2006,第6期

机译：DNA药物：基因治疗，DNA疫苗接种和免疫疗法的配方和交付
2. DNA vaccination for cervical cancer: Strategic optimisation of RALA mediated gene delivery from a biodegradable microneedle system [J] . Cole Grace, Ali Ahlam A., McCrudden Cian M., European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V . 2018,第期

机译：用于宫颈癌的DNA疫苗：RALA介导的生物降解微针系统的介导基因的战略优化
3. DNA vaccination and gene therapy: optimization and delivery for cancer therapy [J] . Angela M Bodles-Brakhop and Ruxandra Draghia-Akli† Expert Review of Vaccines . 2008,第7期

机译：DNA疫苗接种和基因治疗：癌症治疗的优化和交付
4. Multilayer-coated Microneedle Arrays: A Materials Platform for Transdermal Delivery of Plasmid DNA and Degradable Polymer Nanoparticles [C] . Peter DeMuth, Paula T. Hammond, Darrell J. Irvine Annual meeting exposition of the Controlled Release Society . 2011

机译：多层涂层的微针阵列：质粒DNA和可降解的聚合物纳米粒子的透皮递送的材料平台。
5. The synthesis and characterization of novel biomaterials from natural building blocks: Biomaterials research: Past, present, and future directions, and, Saccharide-derived polymers as protein resistant biomaterials, and, Saccharide-peptide copolymers for gene delivery applications, and, Saccharide-peptide copolymer hydrogels for extracellular scaffold design. [D] . Metzke, Mark Adam. 2006

机译：从天然构件中合成和表征新型生物材料：生物材料研究：过去，现在和未来的方向，以及，糖衍生的聚合物作为抗蛋白质生物材料，以及用于基因传递应用的糖肽共聚物，以及糖肽共聚物水凝胶用于细胞外支架设计。
6. Polymeric Materials for Gene Delivery and DNA Vaccination [O] . Dr. David N. Nguyen, Jordan J. Green, Juliana M. Chan, -1

机译：用于基因传递和DNA疫苗接种的聚合材料
7. DNA vaccination for cervical cancer; a novel technology platform of RALA mediated gene delivery via polymeric microneedles. [O] . Ali, Aham A., McCrudden, Cian M., McCaffrey, Joanne, 2017

机译：宫颈癌的DNA疫苗接种； RALA通过聚合的微针介导基因传递的新技术平台。
8. Development of Novel Polymeric Materials for Gene Therapy and pH-Sensitive Drug Delivery: Modeling, Synthesis, Characterization, and Analysis [R] . Anderson, B. C. 2002

机译：用于基因治疗和pH敏感药物递送的新型聚合物材料的开发：建模，合成，表征和分析

Polymeric Materials For Gene Delivery And Dna Vaccination

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