...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced Materials >Bionanocomposites as New Carriers for Influenza Vaccines
【24h】

Bionanocomposites as New Carriers for Influenza Vaccines

机译：Bionanocomposites作为新型的流感疫苗载体

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Bionanocomposites are hybrid materials resulting from the assembly of inorganic nanosized solids with biopolymers, which can provide the biocompatibility required to merge minerals and biological entities such as viral particles. A novel and interesting biomedical application emerging from this feature involves their use as adjuvants for vaccines, in which the bioactivity of the immobilized viruses is preserved. Avian or bird flu is caused by highly pathogenic strains of influenza viruses that jump from animals to humans and, as such, the development of an effective vaccine to protect against a possible pandemic is a matter of urgency. The use of adjuvants based on bionano-composite systems, as proposed here, could make a scarce vaccine suitable for global use with easy administration. The assembly of negatively charged polysaccharides (xanthan gum) and sepiolite, a natural microfibrous silicate, at the nanometer scale results in a novel biohybrid system that is able to associate efficiently to influenza-virus particles, giving very stable water dispersions suitable as intranasal or intramuscular flu vaccines.
机译：离子纳米复合物是由无机纳米级固体与生物聚合物组装而成的杂化材料，可提供融合矿物质和生物实体（如病毒颗粒）所需的生物相容性。从这一特征出现的新颖而有趣的生物医学应用涉及它们作为疫苗的佐剂的用途，其中固定化病毒的生物活性得以保留。禽流感是由高致病性的流感病毒株引起的，它们从动物身上传播到人类，因此，迫切需要开发一种有效的疫苗来预防可能的大流行。如本文中所述，使用基于仿生纳米复合系统的佐剂可以使稀有疫苗适合全球使用且易于管理。带负电荷的多糖（黄原胶）和海泡石（天然微纤维硅酸盐）在纳米级的组装产生了一种新型生物混合系统，该系统能够有效结合流感病毒颗粒，提供非常稳定的水分散液，适合鼻内或肌内流感疫苗。

著录项

  • 来源
    《Advanced Materials》 |2009年第41期|4167-4171|共5页
  • 作者

    Eduardo Ruiz-Hitzky; Margarita Darder; Pilar Aranda; M. Angeles Martin del Burgo; Gustavo del Real;

  • 作者单位

    Institute de Ciencia de Materiales de Madrid, CSIC C/ Sor Juana Ines de la Cruz 3, 28049 Madrid (Spain);

    Institute de Ciencia de Materiales de Madrid, CSIC C/ Sor Juana Ines de la Cruz 3, 28049 Madrid (Spain) Instituto Madrileno de Estudios Avanzados en Materiales (IMDEA-Materiales) C/ Profesor Aranguren s, 28040 Madrid (Spain);

    Institute de Ciencia de Materiales de Madrid, CSIC C/ Sor Juana Ines de la Cruz 3, 28049 Madrid (Spain);

    Department of Biotechnology, INIA Ctra. de la Coruna Km 7,5, 28040 Madrid (Spain);

    Department of Biotechnology, INIA Ctra. de la Coruna Km 7,5, 28040 Madrid (Spain);

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号