Emerging Nanomedicine-Enabled/Enhanced Nanodynamic Therapies beyond Traditional Photodynamics

Hu Hui; Feng Wei; Qian Xiaoqin; Yu Luodan; Chen Yu; Li Yuehua

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Emerging Nanomedicine-Enabled/Enhanced Nanodynamic Therapies beyond Traditional Photodynamics

机译：超出传统光动力动力学的新兴纳米医生的/增强的纳米动力学疗法

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The rapid knowledge growth of nanomedicine and nanobiotechnology enables and promotes the emergence of distinctive disease-specific therapeutic modalities, among which nanomedicine-enabled/augmented nanodynamic therapy (NDT), as triggered by either exogenous or endogenous activators on nanosensitizers, can generate reactive radicals for accomplishing efficient disease nanotherapies with mitigated side effects and endowed disease specificity. As one of the most representative modalities of NDT, traditional light-activated photodynamics suffers from the critical and unsurmountable issues of the low tissue-penetration depth of light and the phototoxicity of the photosensitizers. To overcome these obstacles, versatile nanomedicine-enabled/augmented NDTs have been explored for satisfying varied biomedical applications, which strongly depend on the physicochemical properties of the involved nanomedicines and nanosensitizers. These distinctive NDTs refer to sonodynamic therapy (SDT), thermodynamic therapy (TDT), electrodynamic therapy (EDT), piezoelectric dynamic therapy (PZDT), pyroelectric dynamic therapy (PEDT), radiodynamic therapy (RDT), and chemodynamic therapy (CDT). Herein, the critical roles, functions, and biological effects of nanomedicine (e.g., sonosensitizing, photothermal-converting, electronic, piezoelectric, pyroelectric, radiation-sensitizing, and catalytic properties) for enabling the therapeutic procedure of NDTs, are highlighted and discussed, along with the underlying therapeutic principle and optimization strategy for augmenting disease-therapeutic efficacy and biosafety. The present challenges and critical issues on the clinical translations of NDTs are also discussed and clarified.

机译：纳米医生和纳米能力的快速知识增长使得能够促进特殊疾病特异性治疗方式的出现，其中通过纳米腺分蛋的外源或内源性活化剂引发的纳米发酵的能够的纳米动力学治疗（NDT）可以产生活性自由基用缓解副作用实现有效的疾病纳米疗法，赋予疾病特异性。作为NDT最代表性的方式之一，传统的光激活光动力学遭受了低组织渗透深度的临界和不可克服的问题，以及光敏剂的光毒性。为了克服这些障碍，已经探索了满足各种生物医学应用的通用纳米医疗启用的/增强的NDT，这强烈取决于所涉及的纳米胺和纳米溶剂剂的物理化学性质。这些独特的NDTS指的是铿ody性治疗（SDT），热力学治疗（TDT），电动治疗（EDT），压电动力学治疗（PZDT），热电动态治疗（PEDT），放射性疗法（RDT）和化学动力学治疗（CDT）。在本文中，纳米胺的临界作用，功能和生物学效应（例如，超声溶解，光热转换，电子，压电，热电，辐射致敏和催化性质），并突出显示并讨论了NDT的治疗程序，并讨论随着增强疾病治疗疗效和生物安全性的潜在治疗原理和优化策略。还讨论并澄清了对NDTS临床翻译的挑战和关键问题。

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来源
《Advanced Materials》 |2021年第12期|2005062.1-2005062.24|共24页
作者
Hu Hui; Feng Wei; Qian Xiaoqin; Yu Luodan; Chen Yu; Li Yuehua;
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作者单位

Jiangsu Univ Affiliated Peoples Hosp Medmat Res Ctr Zhenjiang 212002 Jiangsu Peoples R China|Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6 Inst Diagnost & Intervent Radiol Shanghai 200233 Peoples R China;

Shanghai Univ Sch Life Sci Shanghai 2000444 Peoples R China;

Jiangsu Univ Affiliated Peoples Hosp Medmat Res Ctr Zhenjiang 212002 Jiangsu Peoples R China;

Shanghai Univ Sch Life Sci Shanghai 2000444 Peoples R China;

Shanghai Univ Sch Life Sci Shanghai 2000444 Peoples R China|Chinese Acad Sci Shanghai Inst Ceram State Key Lab High Performance Ceram & Superfine Shanghai 200050 Peoples R China;

Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6 Inst Diagnost & Intervent Radiol Shanghai 200233 Peoples R China;

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原文格式 PDF
正文语种 eng
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nanodynamic therapy; nanomedicine; oxidative therapy; radicals; tumor therapy;

机译：纳米动力学;纳米医生;氧化疗法;自由基;肿瘤治疗;

Emerging Nanomedicine-Enabled/Enhanced Nanodynamic Therapies beyond Traditional Photodynamics

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