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A High-Performance Magnetic Resonance Imaging T_2 Contrast Agent

机译：高性能磁共振成像T_2造影剂

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摘要

Magnetic resonance imaging (MRI) has been recognized as one of the best noninvasive imaging modalities in both clinical and research fields because of its ability to provide a wealth of spatial and temporal information with excellent resolution. The MRI mechanisms are based on excitation and relaxation of hydrogen nuclei that are abundant in water and lipids of tissue. Intrinsic longitudinal (T_1) and transverse (T_2) relaxation times of different parts of the tissues bring about changes of MR signal intensity, which in turn results in an imaging contrast. The relaxation times can be manipulated by the use of T_1 (e.g., gadolinium or manganese chelates) and T_2 (e.g., particulate iron oxide) contrast agents, producing brighter (T_1-weighted) and darker (T_2-weighted) images where they are accumulated.
机译：磁共振成像（MRI）被认为是临床和研究领域中最好的非侵入性成像方式之一，因为它能够以出色的分辨率提供大量的时空信息。 MRI机制是基于水和组织脂质中丰富的氢核的激发和弛豫。组织不同部位的内在纵向（T_1）和横向（T_2）弛豫时间导致MR信号强度发生变化，进而导致成像对比度。弛豫时间可以通过使用T_1（例如g或锰螯合物）和T_2（例如颗粒状氧化铁）造影剂来控制，从而产生较亮（T_1加权）和较暗（T_2加权）的图像，并在这些图像上进行累积。

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