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Bubble Forming Films for Spatial Selective Cell Killing

机译：用于空间选择性细胞杀伤的泡沫形成薄膜

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摘要

Photodynamic and photothermal cell killing at the surface of tissues finds applications in medicine. However, a lack of control over heat dissipation following a treatment with light might damage surrounding tissues. A new strategy to kill cells at the surface of tissues is reported. Polymeric films are designed in which iron oxide nanoparticles are embedded as photosensitizers. Irradiation of the films with pulsed laser light generates water vapor bubbles at the surface of the films. It is found that "bubble-films" can kill cells in close proximity to the films due to mechanical forces which arise when the bubbles collapse. Local irradiation of bubble-films allows for spatial selective single cell killing. As nanosurgery becomes attractive in ophthalmology to remove superficial tumors, bubble-films are applied on the cornea and found that irradiation of the bubble-films allows spatial and selective killing of corneal cells. As i) the photosensitizer is embedded in the films, which reduces its uptake by cells and spreading into tissues and ii) the bubble-films can be removed from the tissue after laser treatment, while iii) a low laser fluence is sufficient to generate vapor bubbles, it is foreseen that bubble-films might become promising for safe resection of superficial tumors.
机译：在组织表面的光动力和光热细胞杀死在医学中发现了应用。然而，在用光的处理后缺乏对散热的控制可能会损害周围组织。据报道了一种新的杀灭组织表面细胞的策略。设计聚合物膜，其中氧化铁纳米颗粒嵌入光敏剂中。用脉冲激光照射膜在薄膜表面产生水蒸气气泡。发现“泡泡膜”可以杀死由于气泡坍塌时产生的机械力而在薄膜附近的细胞。泡泡膜的局部照射允许空间选择性单细胞杀伤。由于纳米胸肉在眼科中具有吸引力以去除浅表肿瘤，因此在角膜上施加气泡膜，发现气泡膜的照射允许对角膜细胞的空间和选择性杀死角膜细胞。因为i）光敏剂嵌入薄膜中，这将其通过细胞的吸收降低并扩散到组织中，II）可以在激光处理后从组织中除去气泡膜，而iii）较低的激光器流量足以产生蒸汽。泡沫，预见到泡泡膜可能是安全切除浅表肿瘤的承诺。

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  • 来源
    《Advanced Materials》 |2021年第27期|2008379.1-2008379.15|共15页
  • 作者

    Hua Dawei; Harizaj Aranit; Wels Mike; Brans Toon; Stremersch Stephan; De Keersmaecker Herlinde; Bolea-Fernandez Eduardo; Vanhaecke Frank; Roels Dimitri; Braeckmans Kevin; Xiong Ranhua; Huang Chaobo; De Smedt Stefaan C.; Sauvage Felix;

  • 作者单位

    Nanjing Forestry Univ NFU Coll Chem Engn Joint Lab Adv Biomed Mat NFU UGent Nanjing 210037 Peoples R China|Univ Ghent Fac Pharmaceut Sci Lab Gen Biochem & Phys Pharm B-9000 Ghent Belgium;

    Univ Ghent Fac Pharmaceut Sci Lab Gen Biochem & Phys Pharm B-9000 Ghent Belgium;

    Univ Ghent Fac Pharmaceut Sci Lab Gen Biochem & Phys Pharm B-9000 Ghent Belgium;

    Univ Ghent Fac Pharmaceut Sci Lab Gen Biochem & Phys Pharm B-9000 Ghent Belgium;

    Univ Ghent Fac Pharmaceut Sci Lab Gen Biochem & Phys Pharm B-9000 Ghent Belgium;

    Univ Ghent Fac Pharmaceut Sci Lab Gen Biochem & Phys Pharm B-9000 Ghent Belgium;

    Univ Ghent Dept Chem Atom & Mass Spectrometry A&MS Res Grp Campus Sterre Krijgslaan 281-S12 B-9000 Ghent Belgium;

    Univ Ghent Dept Chem Atom & Mass Spectrometry A&MS Res Grp Campus Sterre Krijgslaan 281-S12 B-9000 Ghent Belgium;

    Ghent Univ Hosp Dept Ophthalmol Corneel Heymanslaan 10 B-9000 Ghent Belgium;

    Univ Ghent Fac Pharmaceut Sci Lab Gen Biochem & Phys Pharm B-9000 Ghent Belgium;

    Nanjing Forestry Univ NFU Coll Chem Engn Joint Lab Adv Biomed Mat NFU UGent Nanjing 210037 Peoples R China|Univ Ghent Fac Pharmaceut Sci Lab Gen Biochem & Phys Pharm B-9000 Ghent Belgium;

    Nanjing Forestry Univ NFU Coll Chem Engn Joint Lab Adv Biomed Mat NFU UGent Nanjing 210037 Peoples R China|Univ Ghent Fac Pharmaceut Sci Lab Gen Biochem & Phys Pharm B-9000 Ghent Belgium;

    Nanjing Forestry Univ NFU Coll Chem Engn Joint Lab Adv Biomed Mat NFU UGent Nanjing 210037 Peoples R China|Univ Ghent Fac Pharmaceut Sci Lab Gen Biochem & Phys Pharm B-9000 Ghent Belgium;

    Univ Ghent Fac Pharmaceut Sci Lab Gen Biochem & Phys Pharm B-9000 Ghent Belgium;

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  • 正文语种 eng
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  • 关键词

    cornea; nanosurgery; photoablation; photodynamic therapy; single cell killing;

    机译：角膜;纳米射出;拍摄;光动力疗法;单细胞杀戮;

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