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首页> 外文期刊>Advanced Materials >Near-Infrared-Light Remote-Controlled Activation of Cancer Immunotherapy Using Photothermal Conjugated Polymer Nanoparticles
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Near-Infrared-Light Remote-Controlled Activation of Cancer Immunotherapy Using Photothermal Conjugated Polymer Nanoparticles

机译：使用光热缀合的聚合物纳米粒子近红外光远温控制癌症免疫疗法

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摘要

Remote control of the therapeutic process is an ideal strategy for maximizing efficacy and avoiding side effects, especially for cancer immunotherapy. Herein, a conjugated polymer nanoparticles (CPNs)-mediated optogenetic system for in situ activation of immunotherapy under near-infrared laser irradiation is reported. This system is composed of photothermal CPNs and interferon-gamma (IFN-gamma) plasmid driven by heat shock promoter HSP70. The photothermally responsive CPNs serve as a photo-heat nanotransducer to trigger the gene transcription of IFN-gamma cytokine. The secreted IFN-gamma from cancer cells can sufficiently elicit surrounding tumor-associated macrophages activation through IFN-gamma-JAK-STAT1 transcription-factor signaling pathway and finally induce cancer cell killing by immunotherapy. Therefore, this synergetic optogenetic system provides a promising approach to remotely control the process of cancer immunotherapy.
机译：遥控治疗过程是最大化疗效和避免副作用的理想策略，尤其是癌症免疫疗法。 这里，报道了用于在近红外激光照射下的用于原位激活免疫疗法的共轭聚合物纳米颗粒（CPNS）介导的致敏系统。 该系统由由热休克启动子HSP70驱动的光热CPNS和干扰素-γ（IFN-Gamma）质粒组成。 光热响应性CPNS用作光热纳米转车器，以触发IFN-Gamma细胞因子的基因转录。 通过IFN-Gamma-Jak-Stat1转录因子信号通路，来自癌细胞的分泌的IFN-Gamma可以充分地引发周围的肿瘤相关的巨噬细胞活化，最后通过免疫疗法诱导癌细胞杀伤。 因此，这种协同致敏系统提供了远程控制癌症免疫疗法过程的有希望的方法。

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  • 来源
    《Advanced Materials》 |2021年第34期|2102570.1-2102570.7|共10页
  • 作者

    Fu Xuancheng; Huang Yiming; Zhao Hao; Zhang Endong; Shen Qi; Di Yufei; Lv Fengting; Liu Libing; Wang Shu;

  • 作者单位

    Chinese Acad Sci Inst Chem Key Lab Organ Solids Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China|Univ Chinese Acad Sci Coll Chem Beijing 100049 Peoples R China;

    Chinese Acad Sci Inst Chem Key Lab Organ Solids Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China;

    Chinese Acad Sci Inst Chem Key Lab Organ Solids Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China;

    Chinese Acad Sci Inst Chem Key Lab Organ Solids Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China|Univ Chinese Acad Sci Coll Chem Beijing 100049 Peoples R China;

    Chinese Acad Sci Inst Chem Key Lab Organ Solids Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China|Univ Chinese Acad Sci Coll Chem Beijing 100049 Peoples R China;

    Chinese Acad Sci Inst Chem Key Lab Organ Solids Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China|Univ Chinese Acad Sci Coll Chem Beijing 100049 Peoples R China;

    Chinese Acad Sci Inst Chem Key Lab Organ Solids Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China;

    Chinese Acad Sci Inst Chem Key Lab Organ Solids Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China;

    Chinese Acad Sci Inst Chem Key Lab Organ Solids Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China|Univ Chinese Acad Sci Coll Chem Beijing 100049 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    cancer immunotherapy; conjugated polymers nanoparticles; optogenetics; remote-controlled activation;

    机译：癌症免疫疗法;共轭聚合物纳米颗粒;光学学;遥控激活;

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