High-Resolution Imaging of Human Viruses in Liquid Droplets

Jonaid G. M.; Dearnaley William J.; Casasanta Michael A.; Kaylor Liam; Berry Samantha; Dukes Madeline J.; Spilman Michael S.; Gray Jennifer L.; Kelly Deborah F.

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High-Resolution Imaging of Human Viruses in Liquid Droplets

机译：液滴中人类病毒的高分辨率成像

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Liquid-phase electron microscopy (LP-EM) is an exciting new area in the materials imaging field, providing unprecedented views of molecular processes. Time-resolved insights from LP-EM studies are a strong complement to the remarkable results achievable with other high-resolution techniques. Here, the opportunities to expand LP-EM technology beyond 2D temporal assessments and into the 3D regime are described. The results show new structures and dynamic insights of human viruses contained in minute volumes of liquid while acquired in a rapid timeframe. To develop this strategy, adeno-associated virus (AAV) is used as a model system. AAV is a well-known gene therapy vehicle with current applications involving drug delivery and vaccine development for COVID-19. Improving the understanding of the physical properties of biological entities in a liquid state, as maintained in the human body, has broad societal implications for human health and disease.

机译：液相电子显微镜（LP-EM）是材料成像场中的令人兴奋的新区域，提供了分子过程的前所未有的视图。 LP-EM研究的时间分辨洞察力是与其他高分辨率技术可实现的显着成果的强烈补充。这里，描述了扩展超出2D时间评估和3D制度的LP-EM技术的机会。结果表明，在快速时隙中获得的微小体积液体中包含的人类病毒的新结构和动态见解。要开发此策略，adeno相关的病毒（aav）用作模型系统。 AAV是一种着名的基因治疗型载体，具有当前应用涉及Covid-19的药物递送和疫苗开发。改善对人体维持的液态生物实体的物理性质的理解，对人体健康和疾病具有广泛的社会影响。

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来源
《Advanced Materials》 |2021年第37期|2103221.1-2103221.13|共13页
作者
Jonaid G. M.; Dearnaley William J.; Casasanta Michael A.; Kaylor Liam; Berry Samantha; Dukes Madeline J.; Spilman Michael S.; Gray Jennifer L.; Kelly Deborah F.;
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Penn State Univ Bioinformat & Genom Grad Program Huck Inst Life Sci University Pk PA 16802 USA|Penn State Univ Dept Biomed Engn University Pk PA 16802 USA|Penn State Univ Mat Res Inst University Pk PA 16802 USA|Penn State Univ Ctr Struct Oncol University Pk PA 16802 USA;

Penn State Univ Dept Biomed Engn University Pk PA 16802 USA|Penn State Univ Mat Res Inst University Pk PA 16802 USA|Penn State Univ Ctr Struct Oncol University Pk PA 16802 USA;

Penn State Univ Dept Biomed Engn University Pk PA 16802 USA|Penn State Univ Mat Res Inst University Pk PA 16802 USA|Penn State Univ Ctr Struct Oncol University Pk PA 16802 USA;

Penn State Univ Dept Biomed Engn University Pk PA 16802 USA|Penn State Univ Mat Res Inst University Pk PA 16802 USA|Penn State Univ Ctr Struct Oncol University Pk PA 16802 USA|Penn State Univ Mol Cellular & Integrat Biosci Grad Program Huck Inst Life Sci University Pk PA 16802 USA;

Penn State Univ Dept Biomed Engn University Pk PA 16802 USA|Penn State Univ Mat Res Inst University Pk PA 16802 USA|Penn State Univ Ctr Struct Oncol University Pk PA 16802 USA;

Protochips Inc Morrisville NC 27560 USA;

Direct Electron LP San Diego CA 92128 USA;

Penn State Univ Mat Res Inst University Pk PA 16802 USA;

Penn State Univ Dept Biomed Engn University Pk PA 16802 USA|Penn State Univ Mat Res Inst University Pk PA 16802 USA|Penn State Univ Ctr Struct Oncol University Pk PA 16802 USA;

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正文语种 eng
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关键词
adeno-associated virus; COVID-19; direct electron detector; liquid-phase electron microscopy; SARS-CoV-2; silicon nitride;

机译：腺相关病毒;Covid-19;直接电子探测器;液相电子显微镜;SARS-COV-2;氮化硅;

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2. High-resolution monochrome liquid crystal display versus efficient household colour liquid crystal display: comparison of their diagnostic performance with unenhanced CT images in focal liver lesions [J] . Yusuke Kawasumi, Takayuki Yamada, Hideki Ota, European Radiology . 2008,第10期

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High-Resolution Imaging of Human Viruses in Liquid Droplets

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