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首页> 外文期刊>Advances in Therapy >Speed of bacterial kill with a fluoroquinolone compared with nonfluoroquinolones: Clinical implications and a review of kinetics of kill studies
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Speed of bacterial kill with a fluoroquinolone compared with nonfluoroquinolones: Clinical implications and a review of kinetics of kill studies

机译：与非氟喹诺酮类药物相比，氟喹诺酮类药物杀死细菌的速度：临床意义和杀伤动力学研究综述

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摘要

It is important to rapidly eradicate bacteria in patients with bacterial conjunctivitis in order to decrease disease transmission, shorten symptom duration, and minimize the emergence of resistant bacteria. This paper presents the results of kinetics of kill studies on 3 commonly isolated pathogens in bacterial conjunctivitis. A more rapid speed of kill with moxifloxacin compared with other nonfluoroquinolone antibiotics (tobramycin, gentamicin, polymyxin B/trimethoprim, or azithromycin) was observed inStaphylococcus aureus, Streptococcus pneumoniae, andHaemophilus influenzae infections. Moxifloxacin achieved a 99.9% kill at approximately 1 h for Saureus, 2 h for Spneumoniae, and 30 min forH influenzae. In comparison, other nonfluoroquinolone therapies took longer to achieve a bactericidal (3-log) kill and some demonstrated no change or an increase in bacterial growth. Based on these findings, it is concluded that moxifloxacin kills bacteria more rapidly than nonfluoroquinolone topical ocular antibiotics.
机译：对于细菌性结膜炎患者，快速消灭细菌很重要，以减少疾病传播，缩短症状持续时间并最大程度减少耐药菌的出现。本文介绍了对细菌性结膜炎中3种常见病原体进行杀灭动力学的动力学研究结果。在金黄色葡萄球菌，肺炎链球菌和流感嗜血杆菌感染中，与其他非氟喹诺酮类抗生素（妥布霉素，庆大霉素，多粘菌素B /甲氧苄啶或阿奇霉素）相比，用莫西沙星杀死的速度更快。大约1小时的Saureus，2小时的肺炎肺炎和30分钟的H流感，莫西沙星的杀灭率达到99.9％。相比之下，其他非氟喹诺酮疗法则需要更长的时间才能达到杀菌（3-log）杀灭的效果，有些疗法没有改变或细菌生长加快。基于这些发现，可以得出结论，莫西沙星比非氟喹诺酮类局部眼用抗生素杀死细菌的速度更快。

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