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The partial contribution of specific airborne pollen to pollen induced allergy

机译:特定的机载花粉对花粉诱发的过敏的部分贡献

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The air that we inhale contains simultaneously a multiple array of allergenic pollen. It is well known that such allergens cause allergic reactions in some 15% of the population of the Western World. However little is known about the quantitative aspect of this phenomenon. What is the lowest concentration of pollen that might trigger allergic responses? As people are exposed to heterogeneous and variable environments, clarification of the partial contribution of each of the major airborne pollen allergens and determination of its role in invoking allergy are of prime importance. Objectives: (1) Assessment of a possible correlation between the concentration of airborne pollen and incidence of allergy. (2) Estimation of the lowest average concentrations for various species of airborne pollen that elicit allergic symptoms when exceeded. (3) Determination of the extent of the variations in manifestation of allergy symptoms that can be explained by fluctuations in the concentration of individual species of airborne pollen. Methods: The study was conducted during 14 months with a rural population in Israel. The participants completed a detailed questionnaire and were skin prick tested with the common airborne allergens. The appearance of clinical symptoms, i.e. nasal, bronchial, ocular or dermal, were reported daily by the patients. Concentrations of the airborne pollen and spores were monitored in the center of activity of the residents during one day every week, using three 'Rotorod' pollen traps. The pollen grains were identified by light microscopy. Results: The pollen spectrum was divided into time-blocks presenting the main pollination periods of the investigated species. The correlation between the concentration of airborne pollen of the relevant species and the clinical symptoms of the patients was determined for each time block. The correlation differed for different clinical symptoms and for different pollen allergens. Highest correlation with airborne pollen counts was found for patients with nasal and bronchial symptoms. The onset of the clinical symptoms by sensitive patients started, in each of the relevant groups, once the weekly average concentration of the airborne pollen crossed a threshold level. Under the limitations of the present study, this level was estimated to be 2-4 pollen m~(-3) air for olive, 3-5 pollen m~(-3) air for grasses, 4-5 pollen m~(-3) air for Artemisia, 10-20 pollen m~(-3) air for pecan and 50-60 pollen m~(-3) air for cypress. Conclusions: Fluctuations in specific airborne pollen grains explained up to 2/3 of the variation in clinical allergy responses. Those were: 69% of the variation for cypress (March-April), 66% for the grasses (March-April), 49% for the pecan (May-June) and 62% for Artemisia (Autumn).
机译:我们吸入的空气同时包含多种过敏性花粉。众所周知,此类过敏原在西方世界约15%的人口中引起过敏反应。但是,对于这种现象的定量方面知之甚少。可能引起过敏反应的最低花粉浓度是多少?由于人们处于异构和多变的环境中,因此,弄清每种主要的空中花粉过敏原的部分贡献以及确定其在引起过敏中的作用至关重要。目标:(1)评估空气中花粉浓度与过敏发生率之间可能的相关性。 (2)估算各种空气中花粉的最低平均浓度,当超过该浓度时,会引起过敏症状。 (3)确定过敏症状表现形式的变化程度,这可以通过空气传播的花粉中各个物种的浓度波动来解释。方法:该研究在以色列的一个农村人口中进行了14个月。参与者完成了一份详细的调查表,并用常见的空气传播过敏原进行了皮肤点刺测试。患者每天报告临床症状的出现,即鼻,支气管,眼或皮肤的症状。每周有一天使用三个“ Rotorod”花粉阱对居民活动中心的空气中花粉和孢子浓度进行监测。通过光学显微镜鉴定花粉粒。结果:花粉光谱被分为多个时间段,呈现了被调查物种的主要授粉期。对于每个时间段,确定相关物种的空气中花粉浓度与患者临床症状之间的相关性。不同的临床症状和花粉过敏原的相关性也不同。发现具有鼻和支气管症状的患者与空气中花粉计数的最高相关性。一旦空气传播的花粉的每周平均浓度超过阈值水平,在每个相关组中,敏感患者就开始出现临床症状。在本研究的限制下,橄榄的水平估计为2-4花粉m〜(-3)空气,草的水平为3-5花粉m〜(-3),草为4-5花粉m〜(- 3)蒿用空气,山核桃用10-20花粉m〜(-3)空气,柏树用50-60花粉m〜(-3)空气。结论:特定的空气传播的花粉颗粒的波动最多可解释临床过敏反应变化的2/3。分别是:柏树(3月至4月)的变异率为69%,草类(3月至4月)的变异率为66%,山核桃(5月至6月)的变异率为49%,蒿木(秋季)的变异率为62%。

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