Almost 50 years on from the Apollo programme, reality decided to remind the world that blasting humans into orbit with controlled explosions is still full of risk and cannot be taken for granted. Fortunately, in this case, the Soyuz emergency systems, worked as designed, giving the two crew a short but undoubtedly hair-raising ride. This is only the third time a Soyuz has aborted, the last being in 1983, a testament to the extraordinary reliability of this workhorse spacecraft. However, there are now renewed worries over the state of Russia's creaking space infrastructure and its quality control and inspections. Russia is now working on a replacement vehicle to Soyuz - the Federation (see p 26) - but for the crew of the ISS, the need for a Soyuz to return to flight is more urgent, despite food supplies, as the operational life of the current capsule docked to the ISS runs out in early January. With Soyuz currently grounded, the two new US 'space taxis' (Boeing's CST-100 and SpaceX's Crewed Dragon) may just enter service in the nick of time. Both NASA and Roscosmos have expressed confidence in Soyuz-FG, and Soyuz MS-11 is still due to lift-off on 20 December. Should the investigation uncover deeper safety issues, then potentially NASA, Roscosmos and the ISS partners face difficult choices, including the ultimate option of 'de-crewing' the ISS until a US or Russian spacecraft is ready. The option of evacuating humanity's outpost in LEO which has been permanently occupied for nearly 18 years, is probably the safest, yet it is also the one with the worst public and political 'optics' with overtones of surrender - and, like the retirement of Concorde and the Space Shuttle, of progress failing to go forwards.
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机译：6.一种化合物，其包含具有根据20的EP-B1-2563920（SEQ ID NO：80）的具有由20个连接的核苷组成的核碱基序列的修饰的寡核苷酸，其中所述修饰的寡核苷酸包含：由十个连接的脱氧核苷组成的缺口片段;和由五个连接的核苷组成的5'翼区段; 3'翼段由五个连接的核苷组成;其中所述间隙片段位于5'侧翼片段和3'侧翼片段之间，其中每个侧翼片段的每个核苷包含2'-O-甲氧基乙基糖;其中修饰的寡核苷酸的每个胞嘧啶是5-甲基胞嘧啶，并且其中修饰的寡核苷酸的每个核苷间键是硫代磷酸酯键;特别是inotersen;及其衍生物，例如由EP-B1-2563920保护的其盐，包括钠盐。
机译：6.一种化合物，其包含具有根据20的EP-B1-2563920（SEQ ID NO：80）的具有由20个连接的核苷组成的核碱基序列的修饰的寡核苷酸，其中所述修饰的寡核苷酸包含：由十个连接的脱氧核苷组成的缺口片段;和由五个连接的核苷组成的5'翼区段; 3'翼段由五个连接的核苷组成;其中所述间隙片段位于5'侧翼片段和3'侧翼片段之间，其中每个侧翼片段的每个核苷包含2'-O-甲氧基乙基糖;其中修饰的寡核苷酸的每个胞嘧啶是5-甲基胞嘧啶，并且其中修饰的寡核苷酸的每个核苷间键是硫代磷酸酯键;特别是inotersen;及其衍生物，例如由EP-B1-2563920保护的其盐，包括钠盐。
