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首页> 外文期刊>AIDS and Behavior >Adherence to Both Cotrimoxazole and Placebo is Associated with Improved Survival Among HIV-Infected Zambian Children
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Adherence to Both Cotrimoxazole and Placebo is Associated with Improved Survival Among HIV-Infected Zambian Children

机译：复方新诺明和安慰剂的依从性与艾滋病毒感染的赞比亚儿童的存活率提高有关

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摘要

In the CHAP randomized placebo-controlled trial of cotrimoxazole prophylaxis in HIV-infected Zambian children conducted between 2001 and 2003, cotrimoxazole was associated with significant mortality reductions. In a secondary analysis we used Cox regression models to estimate the association between adherence measured by bottle weights and caregiver report and subsequent mortality in children surviving >28 days (n = 496, 153 deaths). Adherence was high and similar in both cotrimoxazole and placebo groups; adherence from bottle weights was 100% at 71% of visits, while caregivers reported 100% adherence at 79% of visits. Every 10% lower adherence to cotrimoxazole or placebo measured by bottle weights was associated with a 10–11% increase in mortality risk. Effects remained after adjustment for baseline predictors of survival and for current and recent change in primary caregiver. Caregiver-reported adherence was not associated with survival. The association between bottle-weight adherence to placebo and survival is likely capturing unmeasured caregiver effects, whose identification will be essential for quantifying the impact of antiretroviral therapy (ART) adherence on clinical outcomes in children.
机译：在2001年至2003年之间对艾滋病毒感染的赞比亚儿童进行的考特莫唑预防性CHAP随机安慰剂对照试验中，考特莫唑显着降低了死亡率。在次要分析中，我们使用Cox回归模型估算了通过瓶重和看护者报告衡量的依从性与存活> 28天的儿童随后的死亡率（n = 496，死亡153）之间的关联。曲美唑和安慰剂组的依从性很高，相似。 71％的就诊者对瓶重的依从性为100％，而护理人员报告为79％的就诊者依从性为100％。以瓶重衡量，对考特莫唑或安慰剂的依从性每降低10％，死亡风险就会增加10-11％。调整基线生存率的预测指标以及主要护理人员当前和近期的变化后，效果仍然存在。护理人员报告的依从性与生存率无关。坚持服用安慰剂与瓶重之间的关联可能捕获了无法衡量的看护者效果，其识别对于量化抗逆转录病毒疗法（ART）坚持对儿童临床结局的影响至关重要。

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  • 来源
    《AIDS and Behavior》 |2009年第1期|33-41|共9页
  • 作者

    A. Sarah Walker; Deborah Ford; Veronica Mulenga; Margaret J. Thomason; Andrew Nunn; Chifumbe Chintu; Diana M. Gibb; David R. Bangsberg;

  • 作者单位

    Medical Research Council Clinical Trials Unit 222 Euston Road London NW1 2DA UK;

    Medical Research Council Clinical Trials Unit 222 Euston Road London NW1 2DA UK;

    University Teaching Hospital Lusaka Zambia;

    Medical Research Council Clinical Trials Unit 222 Euston Road London NW1 2DA UK;

    Medical Research Council Clinical Trials Unit 222 Euston Road London NW1 2DA UK;

    University Teaching Hospital Lusaka Zambia;

    Medical Research Council Clinical Trials Unit 222 Euston Road London NW1 2DA UK;

    University of California San Francisco USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    HIV; Africa; Adherence; Cotrimoxazole;

    机译：HIV;非洲;依从性;复方新诺明;

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