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首页> 外文期刊>AIDS Research and Human Retroviruses >Recreational Drug Use and Risk of Kaposi's Sarcoma in HIV- and HHV-8-Coinfected Homosexual Men
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Recreational Drug Use and Risk of Kaposi's Sarcoma in HIV- and HHV-8-Coinfected Homosexual Men

机译:在HIV和HHV-8合并感染的同性恋男性中,娱乐性药物使用和卡波西肉瘤风险

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摘要

Experimental data suggested that exposure to recreational drugs might adversely affect antitumor immunity, which led us to examine the hypothesis that use of marijuana, cocaine, poppers, and amphetamines might increase the risk of Kaposi's Sarcoma (KS) in HIV- and HHV-8-coinfected homosexual men. We analyzed data prospectively collected from the Multicenter AIDS Cohort Study (MACS) between 1984 and 2002. Among the 1335 HIV- and HHV-8-coinfected white men, 401 KS cases were identified. Multivariable Cox regression models were used to estimate the effects of time-varying recreational drug use on KS risk adjusting for potential confounders. The effects of both recent use (6 months prior) of recreational drugs and lagged exposure (i.e., use from 3 and 5 years prior) were examined. We did not observe any clear association with KS for recent use of any of the four drugs. In the analyses using lagged exposures, KS risk was associated with use of poppers 3–5 years prior [hazard ratio (HR)3 years prior=1.27, 95% CI (0.97–1.67), HR5 years prior=1.46 (1.01–2.13)]. However, no clear dose–response relationship was observed. These findings do not support a biological association between use of these substances and KS development in HIV- and HHV-8-coinfected homosexual men.
机译:实验数据表明,接触休闲药物可能会对抗肿瘤免疫产生不利影响,这使我们检验了以下假设:使用大麻,可卡因,波普尔和苯丙胺可能会增加HIV和HHV-8-中卡波西肉瘤(KS)的风险。共感染同性恋男子。我们分析了从1984年至2002年从多中心艾滋病队列研究(MACS)中收集的数据。在1335名感染HIV和HHV-8的白人中,鉴定出401例KS病例。使用多变量Cox回归模型来估计随时间消遣性毒品使用对潜在混杂因素的KS风险调整的影响。检查了最近使用消遣性药物(6个月之前)和滞后接触(即3到5年之前的使用)的影响。对于这四种药物中的任何一种,我们最近都未发现与KS有明确的关联。在使用滞后暴露进行的分析中,KS风险与使用前3–5年的波普尔有关[危险比(HR) 3年前 = 1.27、95%CI(0.97-1.67),HR < sub> 5年之前 = 1.46(1.01–2.13)]。但是,没有观察到明确的剂量反应关系。这些发现不支持在HIV和HHV-8感染的同性恋男性中使用这些物质与KS的发展之间存在生物学联系。

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  • 来源
    《AIDS Research and Human Retroviruses》 |2009年第2期|149-156|共8页
  • 作者单位

    Department of Epidemiology and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, California 90095.;

    Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205.;

    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213.;

    Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095.;

    Departments of Obstetrics and Gynecology and Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California 90095.;

    Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095.;

    Department of Epidemiology and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, California 90095.;

    Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205.;

    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.;

    Department of Epidemiology and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, California 90095.;

    Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095.;

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