...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>AIDS Research and Human Retroviruses >In Utero HIV Infection Is Associated with an Increased Risk of Nevirapine Resistance in Ugandan Infants Who Were Exposed to Perinatal Single Dose Nevirapine
【24h】

In Utero HIV Infection Is Associated with an Increased Risk of Nevirapine Resistance in Ugandan Infants Who Were Exposed to Perinatal Single Dose Nevirapine

机译：子宫内HIV感染与围产期单剂量奈韦拉平接触的乌干达婴儿中奈韦拉平耐药的风险增加相关

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Use of single dose nevirapine (sdNVP) to prevent HIV mother-to-child transmission is associated with the emergence of NVP resistance in many infants who are HIV infected despite prophylaxis. We combined results from four clinical trials to analyze predictors of NVP resistance in sdNVP-exposed Ugandan infants. Samples were tested with the ViroSeq HIV Genotyping System and a sensitive point mutation assay (LigAmp, for detection of K103N, Y181C, and G190A). NVP resistance was detected at 6–8 weeks in 36 (45.0%) of 80 infants using ViroSeq and 33 (45.8%) of 72 infants using LigAmp. NVP resistance was more frequent among infants who were infected in utero than among infants who were diagnosed with HIV infection after birth by 6–8 weeks of age. Detection of NVP resistance at 6–8 weeks was not associated with HIV subtype (A vs. D), pre-NVP maternal viral load or CD4 cell count, infant viral load at 6–8 weeks, or infant sex. NVP resistance was still detected in some infants 6–12 months after sdNVP exposure. In this study, in utero HIV infection was the only factor associated with detection of NVP resistance in infants 6–8 weeks after sdNVP exposure.
机译：使用单剂量奈韦拉平（sdNVP）预防HIV母婴传播与许多尽管预防措施仍被HIV感染的婴儿出现NVP耐药性有关。我们结合了来自四个临床试验的结果，以分析暴露于sdNVP的乌干达婴儿中NVP抵抗力的预测因子。使用ViroSeq HIV基因分型系统和敏感点突变分析（LigAmp，用于检测K103N，Y181C和G190A）测试样品。在使用ViroSeq的80例婴儿中有36（45.0％）名在6-8周时检测到NVP耐药，在使用LigAmp的72例婴儿中有33（45.8％）名中有NVP耐药。在子宫内感染的婴儿中，NVP抵抗力比在6至8周龄出生后被诊断出感染HIV的婴儿更为频繁。在6-8周时检测到NVP抵抗力与HIV亚型（A vs. D），NVP之前的母亲病毒载量或CD4细胞计数，6-8周婴儿病毒载量或性别无关。在sdNVP暴露后6-12个月的某些婴儿中仍检测到NVP抵抗力。在这项研究中，子宫内HIV感染是与sdNVP接触后6-8周婴儿检测NVP耐药性相关的唯一因素。

著录项

  • 来源
    《AIDS Research and Human Retroviruses》 |2009年第7期|673-677|共5页
  • 作者

    Jessica D. Church; Anthony Mwatha; Danstan Bagenda; Saad B. Omer; Deborah Donnell; Philippa Musoke; Clemensia Nakabiito; Chineta Eure; Paul Bakaki; Flavia Matovu; Michael C. Thigpen; Laura A. Guay; Michelle McConnell; Mary Glenn Fowler; J. Brooks Jackson; Susan H. Eshleman;

  • 作者单位

    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.;

    Statistical Center for HIV/AIDS Research and Prevention (SCHARP), Seattle, Washington 98109.;

    Makerere University–Johns Hopkins University (MUJHU) Research Collaboration, Kampala, Uganda.;

    Present address: Emory University, Atlanta, Georgia.;

    Statistical Center for HIV/AIDS Research and Prevention (SCHARP), Seattle, Washington 98109.;

    Makerere University School of Medicine, Kampala, Uganda.;

    Makerere University School of Medicine, Kampala, Uganda.;

    Centers for Disease Control and Prevention (CDC), Atlanta, Georgia 30333.;

    Case Western Reserve University, Cleveland, Ohio 44106.;

    Makerere University–Johns Hopkins University (MUJHU) Research Collaboration, Kampala, Uganda.;

    Centers for Disease Control and Prevention (CDC), Atlanta, Georgia 30333.;

    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.;

    Centers for Disease Control and Prevention (CDC), Atlanta, Georgia 30333.;

    Present address: Johns Hopkins University School of Medicine, Baltimore, Maryland.;

    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.;

    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号