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首页> 外文期刊>AIDS Research and Human Retroviruses >Exercise Training Reduces Central Adiposity and Improves Metabolic Indices in HAART-Treated HIV-Positive Subjects in Rwanda: A Randomized Controlled Trial
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Exercise Training Reduces Central Adiposity and Improves Metabolic Indices in HAART-Treated HIV-Positive Subjects in Rwanda: A Randomized Controlled Trial

机译：运动训练可减少卢旺达接受HAART治疗的HIV阳性受试者的中央肥胖并改善代谢指标：一项随机对照试验。

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As HAART becomes more accessible in sub-Saharan Africa, metabolic syndromes, body fat redistribution (BFR), and cardiovascular disease may become more prevalent. We conducted a 6-month, randomized controlled trial to test whether cardiorespiratory exercise training (CET), improves metabolic, body composition and cardiorespiratory fitness parameters in HAART-treated HIV+ African subjects with BFR. Six months of CET reduced waist circumference (−7.13 ± 4.4 cm, p < 0.0001), WHR (−0.10 ± 0.1, p < 0.0001), sum skinfold thickness (−6.15 ± 8.2 mm, p < 0.0001) and % body fat mass (−1.5 ± 3.3, p < 0.0001) in HIV+BFR+EXS. Hip circumference was unchanged in non-exercise control groups. CET reduced fasting total cholesterol (−0.03 ± 1.11 mM, p < 0.05), triglycerides (−0.22 ±0.48 mM, p < 0.05) and glucose levels (−0.21 ± 0.71 mM, p < 0.05) (p < 0.0001). HDL-, LDL-cholesterol and HOMA values were unchanged after CET. Interestingly, HIV+ subjects randomized to non-exercising groups experienced increases in fasting plasma glucose levels, whereas HIV seronegative controls did not (p < 0.001). Predicted VO2 peak increased more in the HIV+BFR+EXS than in all other groups (4.7 ± 3.9 ml/kg/min, p < 0.0001). Exercise training positively modulated body composition and metabolic profiles, and improved cardiorespiratory fitness in HAART-treated HIV+ Africans. These beneficial adaptations imply that exercise training is a safe, inexpensive, practical, and effective treatment for evolving metabolic and cardiovascular syndromes associated with HIV and HAART exposure in resource-limited sub-Saharan countries, where treatment is improving, morbidity and mortality rates are declining, but where minimal resources are available to manage HIVand HAART-associated cardiovascular and metabolic syndromes
机译：随着HAART在撒哈拉以南非洲地区越来越容易获得，新陈代谢综合症，体内脂肪再分配（BFR）和心血管疾病可能变得更加普遍。我们进行了为期6个月的随机对照试验，以测试心肺运动训练（CET）是否能改善经HAART治疗的HIV +非洲BFR患者的代谢，身体成分和心肺健康参数。六个月的CET减少了腰围（−7.13±4.4 cm，p <0.0001），WHR（−0.10±0.1，p <0.0001），总皮褶厚度（−6.15±8.2 mm，p <0.0001）和体脂百分比（+1.5 + 3.3，p <0.0001）在HIV + BFR + EXS中。非运动对照组的臀围无变化。 CET降低了空腹总胆固醇（-0.03±1.11 mM，p <0.05），甘油三酸酯（-0.22±0.48 mM，p <0.05）和葡萄糖水平（-0.21±0.71 mM，p <0.05）（p <0.0001）。 CET后HDL-，LDL-胆固醇和HOMA值保持不变。有趣的是，随机分为非运动组的HIV +受试者的空腹血糖水平升高，而HIV血清阴性对照则没有（p <0.001）。与所有其他组相比，HIV + BFR + EXS中预测的VO2峰值增加更多（4.7±3.9 ml / kg / min，p <0.0001）。运动训练可积极调节人体成分和代谢状况，并改善HAART治疗的HIV +非洲人的心肺适应性。这些有益的适应措施意味着在资源有限的撒哈拉以南国家，运动训练是一种发展，与HIV和HAART暴露相关的新陈代谢和心血管综合症的安全，廉价，实用和有效的治疗方法，治疗水平在不断提高，发病率和死亡率正在下降，但在可用于管理与HIV和HAART相关的心血管和代谢综合征的资源最少的地方

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