...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>AIDS Research and Human Retroviruses >Efficacy of Antiretroviral Drugs in Reducing Mother-to-Child Transmission of HIV in Africa: A Meta-Analysis of Published Clinical Trials
【24h】

Efficacy of Antiretroviral Drugs in Reducing Mother-to-Child Transmission of HIV in Africa: A Meta-Analysis of Published Clinical Trials

机译：抗逆转录病毒药物在减少非洲艾滋病毒母婴传播中的功效：已发表临床试验的荟萃分析

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Antiretroviral drugs (ARVs) have been shown to be efficacious in decreasing mother-to-child transmission (MTCT) of HIV. A summary estimate of the efficacy of ARVs in reducing MTCT is important for modeling and policy decisions. However, no one has hitherto attempted to generate this summary estimate for Africa, the continent with the greatest HIV/AIDS burden. This study estimates the efficacy of ARVs in reducing MTCT in Africa through a meta-analysis of published studies conducted in Africa. Using an a priori protocol, Medline, EMBASE, and the Cochrane Library were searched for primary studies that measured MTCT of HIV, had ARVs as the exposure to the mother, and were conducted in Africa. Extracted data included characteristics of the study, population, quality, exposure, and results. The data were analyzed using a random effects model with each trial arm as a data point. Ten randomized clinical trials conducted in West, East, and Southern Africa published from 1999 to 2007 satisfied the inclusion criteria. They ranged in sample size from 139 to 1797, and used different ARV regimens as the exposure to the mother antepartum, intrapartum, or postpartum, and to the baby. The combined effect estimate of using ARVs is 10.6% (95% CI: 8.6–13.1) transmission at 4–6 weeks and 21.0% (95% CI: 15.5–27.7) transmission for placebo. This represents approximately 50% efficacy. The result is stable and not driven by any single study. All regimens were well tolerated. We conclude that ARV use to reduce MTCT of HIV in Africa is efficacious and well tolerated
机译：抗逆转录病毒药物（ARV）已被证明可有效减少HIV的母婴传播（MTCT）。对抗逆转录病毒药物降低MTCT的功效进行总结估计对于建模和政策决策很重要。但是，迄今为止，没有人试图为非洲这个艾滋病毒/艾滋病负担最大的大陆得出这一概算。这项研究通过对在非洲进行的已发表研究的荟萃分析，评估了抗逆转录病毒药物在降低非洲MTCT中的功效。使用先验方案，在Medline，EMBASE和Cochrane图书馆中搜索了测量HIV的MTCT，对母亲有ARV暴露的主要研究，并在非洲进行了研究。提取的数据包括研究的特征，人群，质量，接触和结果。使用随机效应模型分析数据，每个试验组作为数据点。从1999年到2007年，在西非，东非和南部非洲进行的十项随机临床试验均符合纳入标准。他们的样本量范围为139至1797，并使用了不同的ARV方案作为对产前，产中或产后以及对婴儿的暴露。使用抗逆转录病毒药物的综合效果估计为：在4-6周时传播率为10.6％（95％CI：8.6-13.1），而对于安慰剂而言是21.0％（95％CI：15.5-27.7）。这代表约50％的功效。结果是稳定的，不受任何单个研究的驱动。所有方案均耐受良好。我们得出的结论是，使用抗逆转录病毒药物来减少非洲的艾滋病毒的MTCT是有效的，而且耐受性良好

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号