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Increased cardiovascular risk due to systemic inflammatory changes and enhanced oxidative stress in urban Indian women

机译：印度城市女性因全身性炎症变化和氧化应激增加而增加心血管疾病风险

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The study was undertaken to elucidate the inflammation- and oxidative stress-mediated deterioration of cardiovascular health in urban women exposed to ambient air pollution from vehicular and industrial emissions. A total of 556 urban women (median age, 34 years) and 514 age-matched control women who resided in the rural areas were enrolled. Serum interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-8 (IL-8) were measured by enzyme-linked immunosorbent assay as markers of inflammation. Generation of reactive oxygen species (ROS) by leukocytes was measured by flow cytometry and erythrocytic superoxide dismutase (SOD) was measured by spectrophotometry. Hypertension was diagnosed following the Seventh Report of the Joint Committee. On the days of sampling, data about particulate matter of diameter less than 10 μm (PM10) in city was obtained from website of State Pollution Control Board and that in rural ambience was measured using real-time aerosol monitor. Compared with control, urban women were exposed to higher levels of ambient air pollution; their serum contained significantly higher levels of IL-6, IL-8, TNF-α, and CRP. ROS generation was increased by 49 % while SOD was depleted by 34.9 %. Urban women were more hypertensive compared to their rural counterparts. PM10 levels were positively associated with inflammatory markers, oxidative stress, and hypertension. Exposure to increased levels of ambient air pollution, which are much higher than the set standard levels, predisposes urban women to increased risk of deteriorating cardiovascular health. Systemic inflammation and oxidative stress are assumed to be the key players in this process.
机译：进行这项研究的目的是阐明城市妇女由于受到车辆和工业废气的污染而受到炎症和氧化应激介导的心血管健康恶化的影响。共有556名城市妇女（中位年龄为34岁）和514名与年龄相匹配的对照妇女居住在农村地区。通过酶联免疫吸附法测定血清白细胞介素6（IL-6），C反应蛋白（CRP），肿瘤坏死因子-α（TNF-α）和白细胞介素8（IL-8）作为炎症标志物。通过流式细胞术测量白细胞产生的活性氧（ROS），通过分光光度法测量红细胞超氧化物歧化酶（SOD）。高血压是在联合委员会第七次报告之后被诊断出来的。在采样的那天，从国家污染控制委员会的网站上获取了城市中直径小于10μm（PM10）的颗粒物的数据，并使用实时气溶胶监测仪测量了农村环境中的颗粒物。与对照相比，城市妇女面临着更高水平的环境空气污染。他们的血清中IL-6，IL-8，TNF-α和CRP的含量明显更高。 ROS的产生增加了49％，而SOD则减少了34.9％。与农村妇女相比，城市妇女的高血压更为严重。 PM10水平与炎症标志物，氧化应激和高血压呈正相关。暴露在比设定标准水平高得多的环境空气污染水平下，使城市妇女容易患上心血管健康恶化的风险。全身性炎症和氧化应激被认为是该过程的关键因素。

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